Literature summary extracted from

Sato, A.; Bacon, P.E.; Cory, J.G.
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit (1984), Adv. Enzyme Regul., 22, 231-241.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.17.4.1	2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole	mechanism of inhibition	Mus musculus
1.17.4.1	4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone	inhibits the non-heme iron subunit	Mus musculus
1.17.4.1	4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone	-	Mus musculus
1.17.4.1	H2O2	0.01%, 81% inhibition	Mus musculus
1.17.4.1	Hydroxyurea	inhibits the non-heme iron subunit; mechanism of inhibition	Mus musculus
1.17.4.1	pyrazoloimidazol	-	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.17.4.1	Mus musculus	-	Ehrlich ascites tumor cells	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.17.4.1	Ehrlich ascites carcinoma cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.17.4.1	ribonucleoside diphosphate + reduced thioredoxin	-	Mus musculus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir

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Release 2023.1 (January 2023)