BRENDA - Enzyme Database

Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit

Sato, A.; Bacon, P.E.; Cory, J.G.; Adv. Enzyme Regul. 22, 231-241 (1984)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
mechanism of inhibition
Mus musculus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
inhibits the non-heme iron subunit
Mus musculus
1.17.4.1
4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone
-
Mus musculus
1.17.4.1
H2O2
0.01%, 81% inhibition
Mus musculus
1.17.4.1
Hydroxyurea
inhibits the non-heme iron subunit; mechanism of inhibition
Mus musculus
1.17.4.1
pyrazoloimidazol
-
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.4.1
Mus musculus
-
Ehrlich ascites tumor cells
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437920
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437920
Mus musculus
ir
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
mechanism of inhibition
Mus musculus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
inhibits the non-heme iron subunit
Mus musculus
1.17.4.1
4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone
-
Mus musculus
1.17.4.1
H2O2
0.01%, 81% inhibition
Mus musculus
1.17.4.1
Hydroxyurea
inhibits the non-heme iron subunit; mechanism of inhibition
Mus musculus
1.17.4.1
pyrazoloimidazol
-
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437920
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437920
Mus musculus
ir