BRENDA - Enzyme Database

The ribonucleotide reductases - a unique group of metalloenzymes essential for cell proliferation

Lammers, M.; Follmann, H.; Struct. Bonding 54, 27-91 (1983)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
stimulation of CDP reduction
Mesocricetus auratus
1.17.4.1
ATP
-
Mus musculus
1.17.4.1
ATP
-
Saccharomyces cerevisiae
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
ATP
-
Enterobacteria phage T6
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
ATP
-
Escherichia virus T5
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
ATP
stimulation of CDP reduction
Rattus norvegicus
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
ATP
stimulation of CDP reduction
Tetradesmus obliquus
1.17.4.1
dCTP
stimulation of UDP reduction
Bos taurus
1.17.4.1
dCTP
stimulation of UDP reduction
Escherichia coli
1.17.4.1
dCTP
stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
dCTP
stimulation of UDP reduction
Homo sapiens
1.17.4.1
dCTP
-
Mesocricetus auratus
1.17.4.1
dCTP
stimulation of UDP reduction
Mus musculus
1.17.4.1
dCTP
stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
dCTP
stimulation of UDP reduction
Rattus norvegicus
1.17.4.1
dCTP
stimulation of UDP reduction
Saccharomyces cerevisiae
1.17.4.1
dCTP
stimulation of UDP reduction
Tetradesmus obliquus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Bos taurus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Escherichia coli
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Escherichia virus T4
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Homo sapiens
1.17.4.1
dGTP
-
Mesocricetus auratus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Mus musculus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Oryctolagus cuniculus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Rattus norvegicus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Saccharomyces cerevisiae
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Tetradesmus obliquus
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Mus musculus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Rattus norvegicus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Saccharomyces cerevisiae
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Tetradesmus obliquus
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Bos taurus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia coli
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia virus T4
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Homo sapiens
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Mus musculus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Oryctolagus cuniculus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Rattus norvegicus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Saccharomyces cerevisiae
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Tetradesmus obliquus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
1,10-phenanthroline
-
Bos taurus
1.17.4.1
1,10-phenanthroline
-
Escherichia coli
1.17.4.1
1,10-phenanthroline
-
Escherichia virus T4
1.17.4.1
1,10-phenanthroline
-
Homo sapiens
1.17.4.1
1,10-phenanthroline
-
Mus musculus
1.17.4.1
1,10-phenanthroline
-
Oryctolagus cuniculus
1.17.4.1
1,10-phenanthroline
-
Rattus norvegicus
1.17.4.1
1,10-phenanthroline
-
Saccharomyces cerevisiae
1.17.4.1
1,10-phenanthroline
-
Tetradesmus obliquus
1.17.4.1
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
-
Mus musculus
1.17.4.1
2-Nitro-imidazole
trivial name azomycin
Escherichia coli
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Bos taurus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Homo sapiens
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mesocricetus auratus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mus musculus
1.17.4.1
3-Methyl-4-nitrophenol
-
Mesocricetus auratus
1.17.4.1
4-Amino-2-phenylimidazole-5-carboxamide
-
Rattus norvegicus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Escherichia coli
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Homo sapiens
1.17.4.1
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Rattus norvegicus
1.17.4.1
8-hydroxyquinoline
-
Escherichia coli
1.17.4.1
8-hydroxyquinoline
-
Oryctolagus cuniculus
1.17.4.1
8-hydroxyquinoline
-
Rattus norvegicus
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Escherichia coli
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Oryctolagus cuniculus
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Rattus norvegicus
1.17.4.1
Acetohydroxamic acid
-
Escherichia coli
1.17.4.1
aurintricarboxylate
oligomeric form
Escherichia coli
1.17.4.1
aurintricarboxylate
oligomeric form
Saccharomyces cerevisiae
1.17.4.1
aurintricarboxylate
oligomeric form
Tetradesmus obliquus
1.17.4.1
bathophenanthroline disulfonate
-
Bos taurus
1.17.4.1
bathophenanthroline disulfonate
-
Mus musculus
1.17.4.1
bathophenanthroline disulfonate
-
Oryctolagus cuniculus
1.17.4.1
Catechol derivatives
-
Rattus norvegicus
1.17.4.1
Cibacron blue F3 GA
-
Mus musculus
1.17.4.1
desferrioxamine
-
Homo sapiens
1.17.4.1
EDTA
-
Mesocricetus auratus
1.17.4.1
EDTA
-
Mus musculus
1.17.4.1
EDTA
-
Tetradesmus obliquus
1.17.4.1
EDTA
-
Homo sapiens
1.17.4.1
EDTA
-
Rattus norvegicus
1.17.4.1
EDTA
-
Bos taurus
1.17.4.1
EDTA
-
Escherichia coli
1.17.4.1
ethyleneglycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid
trivial name EGTA
Mus musculus
1.17.4.1
Fe2+
-
Rattus norvegicus
1.17.4.1
Fe2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
1.17.4.1
glutathione
analogs with aromatic substituents
Mus musculus
1.17.4.1
Hydroxyurea
1 mM, complete inactivation of thymus enzyme
Bos taurus
1.17.4.1
Hydroxyurea
-
Mesocricetus auratus
1.17.4.1
Hydroxyurea
-
Saccharomyces cerevisiae
1.17.4.1
Hydroxyurea
-
Tetradesmus obliquus
1.17.4.1
Hydroxyurea
-
Mus musculus
1.17.4.1
Hydroxyurea
-
Escherichia virus T4
1.17.4.1
Hydroxyurea
-
Escherichia virus T5
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Oryctolagus cuniculus
1.17.4.1
Hydroxyurea
-
Homo sapiens
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Bos taurus
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Homo sapiens
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
meso-alpha,beta-Diphenylsuccinate
-
Mus musculus
1.17.4.1
Mn2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Bos taurus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia coli
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia virus T4
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Homo sapiens
1.17.4.1
additional information
-
Mesocricetus auratus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Mus musculus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Oryctolagus cuniculus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Rattus norvegicus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Saccharomyces cerevisiae
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Tetradesmus obliquus
1.17.4.1
n-Hexanohydroxamic acid
-
Escherichia coli
1.17.4.1
N-Methylhydroxylamine
-
Escherichia coli
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Escherichia coli
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Homo sapiens
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
pyridoxal 5'-phosphate/NaBH4
-
Mus musculus
1.17.4.1
Pyrogallol derivatives
-
Rattus norvegicus
1.17.4.1
Thenoyltrifluoroacetone
-
Mus musculus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.17.4.1
Iron
-
Bos taurus
1.17.4.1
Iron
subunit B2 contains iron, nonheme-like porphyrin complexes
Escherichia coli
1.17.4.1
Iron
-
Escherichia virus T4
1.17.4.1
Iron
-
Mus musculus
1.17.4.1
Iron
-
Oryctolagus cuniculus
1.17.4.1
Iron
-
Rattus norvegicus
1.17.4.1
Iron
-
Tetradesmus obliquus
1.17.4.1
Mg2+
2fold stimulation
Bos taurus
1.17.4.1
Mg2+
-
Escherichia virus T4
1.17.4.1
Mg2+
-
Mesocricetus auratus
1.17.4.1
Mg2+
-
Oryctolagus cuniculus
1.17.4.1
Mg2+
subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity
Escherichia coli
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Bos taurus
1.17.4.1
additional information
-
Mus musculus
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Rattus norvegicus
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Saccharomyces cerevisiae
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Tetradesmus obliquus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.17.4.1
35000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
1.17.4.1
39000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
1.17.4.1
45000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
55000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
75000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
75000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
78000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
80000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
1.17.4.1
82000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
84000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
85000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
1.17.4.1
90000
-
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
1.17.4.1
90000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
100000
-
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Tetradesmus obliquus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Tetradesmus obliquus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Mus musculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Mus musculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Escherichia coli
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Homo sapiens
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Homo sapiens
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Rattus norvegicus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Rattus norvegicus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Saccharomyces cerevisiae
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Saccharomyces cerevisiae
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Bos taurus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Bos taurus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Oryctolagus cuniculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Oryctolagus cuniculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Escherichia virus T4
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia virus T4
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.4.1
Bos taurus
-
-
-
1.17.4.1
Enterobacteria phage T6
-
-
-
1.17.4.1
Escherichia coli
-
-
-
1.17.4.1
Escherichia virus T4
-
-
-
1.17.4.1
Escherichia virus T5
-
-
-
1.17.4.1
Homo sapiens
-
Molt 4F cells
-
1.17.4.1
Mesocricetus auratus
-
-
-
1.17.4.1
Mus musculus
-
Ehrlich ascites tumor cells
-
1.17.4.1
Oryctolagus cuniculus
-
-
-
1.17.4.1
Rattus norvegicus
-
Novikoff hepatoma cells
-
1.17.4.1
Saccharomyces cerevisiae
-
-
-
1.17.4.1
Tetradesmus obliquus
-
green algae
-
Reaction
EC Number
Reaction
Commentary
Organism
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Bos taurus
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Escherichia virus T4
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Homo sapiens
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Mus musculus
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Oryctolagus cuniculus
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Rattus norvegicus
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Saccharomyces cerevisiae
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Tetradesmus obliquus
1.17.4.1
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Escherichia coli
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
bone marrow
-
Oryctolagus cuniculus
-
1.17.4.1
Ehrlich ascites carcinoma cell
-
Mus musculus
-
1.17.4.1
liver
regenerating liver
Rattus norvegicus
-
1.17.4.1
lymphoblast
Molt 4F cells
Homo sapiens
-
1.17.4.1
Novikoff ascites tumor cell
-
Rattus norvegicus
-
1.17.4.1
thymus
calf
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
2,6-diaminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2,6-diaminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
2-aminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2-aminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
benzimidazoleriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxybenzimidazolriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
purineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxypurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mesocricetus auratus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mesocricetus auratus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Enterobacteria phage T6
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T5
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
?
1.17.4.1
tubercidin diphosphate + reduced thioredoxin
14% of GDP reduction rate
437918
Escherichia coli
2'-deoxytubercidin diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
Subunits
EC Number
Subunits
Commentary
Organism
1.17.4.1
?
-
Bos taurus
1.17.4.1
?
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
1.17.4.1
?
-
Rattus norvegicus
1.17.4.1
?
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
dimer
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
1.17.4.1
hexamer
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
tetramer
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
tetramer
alpha, alpha',beta2, 2 * 80000 + 2 * 39000, SDS-PAGE; alpha,alpha'beta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
tetramer
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.17.4.1
ATP
stimulation of CDP reduction
Mesocricetus auratus
1.17.4.1
ATP
-
Mus musculus
1.17.4.1
ATP
-
Saccharomyces cerevisiae
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
ATP
-
Enterobacteria phage T6
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
ATP
-
Escherichia virus T5
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
ATP
stimulation of CDP reduction
Rattus norvegicus
1.17.4.1
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
ATP
stimulation of CDP reduction
Tetradesmus obliquus
1.17.4.1
dCTP
stimulation of UDP reduction
Bos taurus
1.17.4.1
dCTP
stimulation of UDP reduction
Escherichia coli
1.17.4.1
dCTP
stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
dCTP
stimulation of UDP reduction
Homo sapiens
1.17.4.1
dCTP
-
Mesocricetus auratus
1.17.4.1
dCTP
stimulation of UDP reduction
Mus musculus
1.17.4.1
dCTP
stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
dCTP
stimulation of UDP reduction
Rattus norvegicus
1.17.4.1
dCTP
stimulation of UDP reduction
Saccharomyces cerevisiae
1.17.4.1
dCTP
stimulation of UDP reduction
Tetradesmus obliquus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Bos taurus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Escherichia coli
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Escherichia virus T4
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Homo sapiens
1.17.4.1
dGTP
-
Mesocricetus auratus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Mus musculus
1.17.4.1
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Oryctolagus cuniculus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Rattus norvegicus
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Saccharomyces cerevisiae
1.17.4.1
dGTP
stimulation of tubercidin diphosphate reduction
Tetradesmus obliquus
1.17.4.1
dGTP
-
Enterobacteria phage T6
1.17.4.1
dGTP
-
Escherichia virus T5
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Bos taurus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia coli
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia virus T4
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Homo sapiens
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Mus musculus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Oryctolagus cuniculus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Rattus norvegicus
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Saccharomyces cerevisiae
1.17.4.1
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Tetradesmus obliquus
1.17.4.1
dTTP
-
Enterobacteria phage T6
1.17.4.1
dTTP
-
Escherichia virus T5
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Bos taurus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia coli
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia virus T4
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Homo sapiens
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Mus musculus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Oryctolagus cuniculus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Rattus norvegicus
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Saccharomyces cerevisiae
1.17.4.1
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Tetradesmus obliquus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.17.4.1
1,10-phenanthroline
-
Bos taurus
1.17.4.1
1,10-phenanthroline
-
Escherichia coli
1.17.4.1
1,10-phenanthroline
-
Escherichia virus T4
1.17.4.1
1,10-phenanthroline
-
Homo sapiens
1.17.4.1
1,10-phenanthroline
-
Mus musculus
1.17.4.1
1,10-phenanthroline
-
Oryctolagus cuniculus
1.17.4.1
1,10-phenanthroline
-
Rattus norvegicus
1.17.4.1
1,10-phenanthroline
-
Saccharomyces cerevisiae
1.17.4.1
1,10-phenanthroline
-
Tetradesmus obliquus
1.17.4.1
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
-
Mus musculus
1.17.4.1
2-Nitro-imidazole
trivial name azomycin
Escherichia coli
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Bos taurus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Homo sapiens
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mesocricetus auratus
1.17.4.1
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mus musculus
1.17.4.1
3-Methyl-4-nitrophenol
-
Mesocricetus auratus
1.17.4.1
4-Amino-2-phenylimidazole-5-carboxamide
-
Rattus norvegicus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Escherichia coli
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Homo sapiens
1.17.4.1
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Rattus norvegicus
1.17.4.1
8-hydroxyquinoline
-
Escherichia coli
1.17.4.1
8-hydroxyquinoline
-
Oryctolagus cuniculus
1.17.4.1
8-hydroxyquinoline
-
Rattus norvegicus
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Escherichia coli
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Oryctolagus cuniculus
1.17.4.1
8-hydroxyquinoline 5-sulfonate
-
Rattus norvegicus
1.17.4.1
Acetohydroxamic acid
-
Escherichia coli
1.17.4.1
aurintricarboxylate
oligomeric form
Escherichia coli
1.17.4.1
aurintricarboxylate
oligomeric form
Saccharomyces cerevisiae
1.17.4.1
aurintricarboxylate
oligomeric form
Tetradesmus obliquus
1.17.4.1
bathophenanthroline disulfonate
-
Bos taurus
1.17.4.1
bathophenanthroline disulfonate
-
Mus musculus
1.17.4.1
bathophenanthroline disulfonate
-
Oryctolagus cuniculus
1.17.4.1
Catechol derivatives
-
Rattus norvegicus
1.17.4.1
Cibacron blue F3 GA
-
Mus musculus
1.17.4.1
desferrioxamine
-
Homo sapiens
1.17.4.1
EDTA
-
Mesocricetus auratus
1.17.4.1
EDTA
-
Mus musculus
1.17.4.1
EDTA
-
Tetradesmus obliquus
1.17.4.1
EDTA
-
Homo sapiens
1.17.4.1
EDTA
-
Rattus norvegicus
1.17.4.1
EDTA
-
Bos taurus
1.17.4.1
EDTA
-
Escherichia coli
1.17.4.1
ethyleneglycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid
trivial name EGTA
Mus musculus
1.17.4.1
Fe2+
-
Rattus norvegicus
1.17.4.1
Fe2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
1.17.4.1
glutathione
analogs with aromatic substituents
Mus musculus
1.17.4.1
Hydroxyurea
1 mM, complete inactivation of thymus enzyme
Bos taurus
1.17.4.1
Hydroxyurea
-
Mesocricetus auratus
1.17.4.1
Hydroxyurea
-
Saccharomyces cerevisiae
1.17.4.1
Hydroxyurea
-
Tetradesmus obliquus
1.17.4.1
Hydroxyurea
-
Mus musculus
1.17.4.1
Hydroxyurea
-
Escherichia virus T4
1.17.4.1
Hydroxyurea
-
Escherichia virus T5
1.17.4.1
Hydroxyurea
-
Rattus norvegicus
1.17.4.1
Hydroxyurea
-
Escherichia coli
1.17.4.1
Hydroxyurea
-
Oryctolagus cuniculus
1.17.4.1
Hydroxyurea
-
Homo sapiens
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Bos taurus
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Homo sapiens
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
meso-alpha,beta-Diphenylsuccinate
-
Mus musculus
1.17.4.1
Mn2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Bos taurus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia coli
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia virus T4
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Homo sapiens
1.17.4.1
additional information
-
Mesocricetus auratus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Mus musculus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Oryctolagus cuniculus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Rattus norvegicus
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Saccharomyces cerevisiae
1.17.4.1
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Tetradesmus obliquus
1.17.4.1
n-Hexanohydroxamic acid
-
Escherichia coli
1.17.4.1
N-Methylhydroxylamine
-
Escherichia coli
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Escherichia coli
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Homo sapiens
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Mus musculus
1.17.4.1
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
1.17.4.1
pyridoxal 5'-phosphate/NaBH4
-
Mus musculus
1.17.4.1
Pyrogallol derivatives
-
Rattus norvegicus
1.17.4.1
Thenoyltrifluoroacetone
-
Mus musculus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.17.4.1
Iron
-
Bos taurus
1.17.4.1
Iron
subunit B2 contains iron, nonheme-like porphyrin complexes
Escherichia coli
1.17.4.1
Iron
-
Escherichia virus T4
1.17.4.1
Iron
-
Mus musculus
1.17.4.1
Iron
-
Oryctolagus cuniculus
1.17.4.1
Iron
-
Rattus norvegicus
1.17.4.1
Iron
-
Tetradesmus obliquus
1.17.4.1
Mg2+
2fold stimulation
Bos taurus
1.17.4.1
Mg2+
-
Escherichia virus T4
1.17.4.1
Mg2+
-
Mesocricetus auratus
1.17.4.1
Mg2+
-
Oryctolagus cuniculus
1.17.4.1
Mg2+
subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity
Escherichia coli
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Bos taurus
1.17.4.1
additional information
-
Mus musculus
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Rattus norvegicus
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Saccharomyces cerevisiae
1.17.4.1
additional information
Mg2+ is not required for activity in vitro
Tetradesmus obliquus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.17.4.1
35000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
1.17.4.1
39000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
1.17.4.1
45000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
55000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
75000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
75000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
78000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
80000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
1.17.4.1
82000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
84000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
85000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
1.17.4.1
90000
-
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
1.17.4.1
90000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
100000
-
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Tetradesmus obliquus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Tetradesmus obliquus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Mus musculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Mus musculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Escherichia coli
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Homo sapiens
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Homo sapiens
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Rattus norvegicus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Rattus norvegicus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Saccharomyces cerevisiae
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Saccharomyces cerevisiae
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Bos taurus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Bos taurus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Oryctolagus cuniculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Oryctolagus cuniculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
Escherichia virus T4
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia virus T4
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.4.1
bone marrow
-
Oryctolagus cuniculus
-
1.17.4.1
Ehrlich ascites carcinoma cell
-
Mus musculus
-
1.17.4.1
liver
regenerating liver
Rattus norvegicus
-
1.17.4.1
lymphoblast
Molt 4F cells
Homo sapiens
-
1.17.4.1
Novikoff ascites tumor cell
-
Rattus norvegicus
-
1.17.4.1
thymus
calf
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.4.1
2,6-diaminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2,6-diaminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
2-aminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2-aminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
benzimidazoleriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxybenzimidazolriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
purineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxypurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mesocricetus auratus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mesocricetus auratus
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Enterobacteria phage T6
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T5
ir
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
?
1.17.4.1
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
?
1.17.4.1
tubercidin diphosphate + reduced thioredoxin
14% of GDP reduction rate
437918
Escherichia coli
2'-deoxytubercidin diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.17.4.1
?
-
Bos taurus
1.17.4.1
?
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
1.17.4.1
?
-
Rattus norvegicus
1.17.4.1
?
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
1.17.4.1
dimer
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
1.17.4.1
hexamer
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
1.17.4.1
tetramer
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
1.17.4.1
tetramer
alpha, alpha',beta2, 2 * 80000 + 2 * 39000, SDS-PAGE; alpha,alpha'beta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
1.17.4.1
tetramer
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4