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Literature summary extracted from

  • Averett, D.R.; Lubbers, C.; Elion, G.B.; Spector, T.
    Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme (1983), J. Biol. Chem., 258, 9831-9838.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.1 3,5-diamino-1H-1,2,4-triazole 2.3 mM, 50% inhibition of CDP reduction, 2.6 mM, 50% inhibition of ADP reduction Mesocricetus auratus
1.17.4.1 ADP
-
 Mesocricetus auratus
1.17.4.1 ATP CDP reduction is inhibited by free ATP Mesocricetus auratus
1.17.4.1 CDP
-
 Mesocricetus auratus
1.17.4.1 dADP product inhibition Mesocricetus auratus
1.17.4.1 dATP 2.1 mM, 50% inhibition; inhibition of CDP reduction; weak inhibition of ADP reduction Mesocricetus auratus
1.17.4.1 dCDP product inhibition Mesocricetus auratus
1.17.4.1 dCTP 1.2 mM, 50% inhibition of CDP reduction, 0.89 mM, 50% inhibition of ADP reduction Mesocricetus auratus
1.17.4.1 dGDP product inhibition Mesocricetus auratus
1.17.4.1 dGTP 1.2 mM, 50% inhibition of CDP reduction, 0.93 mM, 50% inhibition of ADP reduction Mesocricetus auratus
1.17.4.1 dTTP inhibition of CDP reduction Mesocricetus auratus
1.17.4.1 dUDP product inhibition Mesocricetus auratus
1.17.4.1 EDTA
-
 Mesocricetus auratus
1.17.4.1 GDP
-
 Mesocricetus auratus
1.17.4.1 Hydroxyurea
-
 Mesocricetus auratus
1.17.4.1 Mg2+ uncomplexed Mg2+ Mesocricetus auratus
1.17.4.1 additional information each ribonucleoside diphosphate substrate is competitively inhibited by reduction of each other substrate Mesocricetus auratus
1.17.4.1 UDP
-
 Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.1 0.00065
-
 CDP
-
 Mesocricetus auratus
1.17.4.1 0.0012
-
 GDP
-
 Mesocricetus auratus
1.17.4.1 0.012
-
 ADP
-
 Mesocricetus auratus
1.17.4.1 0.08
-
 UDP
-
 Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Mesocricetus auratus
-
 baby hamster kidney cells, enzyme induced by Herpes simplex, virus type 1, HSV-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.1 BHK-21 cell
-
 Mesocricetus auratus
-
1.17.4.1 kidney baby hamster kidney cells Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 ADP + thioredoxin
-
 Mesocricetus auratus 2'-dADP + thioredoxin disulfide + H2O
-
 r
1.17.4.1 CDP + thioredoxin
-
 Mesocricetus auratus 2'-dCDP + thioredoxin disulfide + H2O
-
 r
1.17.4.1 GDP + thioredoxin
-
 Mesocricetus auratus 2'-dGDP + thioredoxin disulfide + H2O
-
 r
1.17.4.1 ribonucleoside diphosphate + reduced thioredoxin
-
 Mesocricetus auratus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
 ir
1.17.4.1 UDP + reduced thioredoxin
-
 Mesocricetus auratus 2'-deoxy-UDP + oxidized thioredoxin + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.4.1 8.1
-
-
 Mesocricetus auratus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.4.1 0.00058
-
 CDP vs. GDP Mesocricetus auratus
1.17.4.1 0.0006
-
 GDP vs. ADP Mesocricetus auratus
1.17.4.1 0.0007
-
 CDP vs. ADP Mesocricetus auratus
1.17.4.1 0.0012
-
 GDP vs. CDP Mesocricetus auratus
1.17.4.1 0.0018
-
 GDP vs. UDP Mesocricetus auratus
1.17.4.1 0.0019
-
 CDP vs. UDP Mesocricetus auratus
1.17.4.1 0.0055
-
 ADP vs. GDP Mesocricetus auratus
1.17.4.1 0.0058
-
 UDP vs. GDP Mesocricetus auratus
1.17.4.1 0.014
-
 ADP vs. CDP Mesocricetus auratus
1.17.4.1 0.036
-
 ADP vs. UDP Mesocricetus auratus
1.17.4.1 0.042
-
 UDP vs. CDP Mesocricetus auratus
1.17.4.1 0.043
-
 UDP vs. ADP Mesocricetus auratus