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Literature summary extracted from

  • Licht, S.S.; Booker, S.; Stubbe, J.
    Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation (1999), Biochemistry, 38, 1221-1233.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.2 0.017
-
dGTP
-
Lactobacillus leichmannii
1.17.4.2 0.06
-
adenosylcobalamin
-
Lactobacillus leichmannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O Escherichia coli
-
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O Lactobacillus leichmannii catalyzes the rate-determining step in DNA biosynthesis 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.2 Escherichia coli
-
-
-
1.17.4.2 Lactobacillus leichmannii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.2 GTP + reduced thioredoxin
-
Lactobacillus leichmannii dGTP + oxidized thioredoxin + H2O
-
?
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin
-
Escherichia coli 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O
-
Escherichia coli 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
1.17.4.2 ribonucleoside triphosphate + reduced thioredoxin + H2O catalyzes the rate-determining step in DNA biosynthesis Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r

Synonyms

EC Number Synonyms Comment Organism
1.17.4.2 RNR
-
Lactobacillus leichmannii
1.17.4.2 RTPR
-
Lactobacillus leichmannii

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.2 coenzyme B12 adenosylcobalamin Lactobacillus leichmannii