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Literature summary extracted from
- Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii (1965), J. Biol. Chem., 240, 2173-2180.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.4.2 | 2',5'-dideoxyadenosylcobalamin anilide | - |
Lactobacillus leichmannii |  |
| 1.17.4.2 | 2-mercaptoethanol | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | 5'-deoxyadenosylcobalamin | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | 5'-deoxyadenosylcobalamin anilide | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | 5'-deoxyuridylcobalamin | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cobinamide | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cyanocobalamin | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cyanocobalamin anilide | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cyanocobalamin dibasic acid | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cyanocobalamin ethylamide | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | cyanocobalamin monobasic acid | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | ethyl cobalamin | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | hydroxocobalamin | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | hydroxocobalamin methylamide | - |
Lactobacillus leichmannii | |
| 1.17.4.2 | methyl cobalamin | - |
Lactobacillus leichmannii | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.2 | ribonucleoside triphosphate + reduced thioredoxin + H2O | Lactobacillus leichmannii | - |
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.4.2 | Lactobacillus leichmannii | - |
mutant of strain ATCC 4797, produced during many years of transfers on litmus milk | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.4.2 | CTP + reduced thioredoxin | - |
Lactobacillus leichmannii | dCTP + oxidized thioredoxin + H2O | - |
? | |
| 1.17.4.2 | ribonucleoside triphosphate + reduced thioredoxin | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
| 1.17.4.2 | ribonucleoside triphosphate + reduced thioredoxin + H2O | - |
Lactobacillus leichmannii | 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O | - |
r | |
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Release 2023.1 (January 2023)
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