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Literature summary extracted from

  • Irmler, S.; Schroder, G.; St-Pierre, B.; Crouch, N.P.; Hotze, M.; Schmidt, J.; Strack, D.; Matern, U.; Schroder, J.
    Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase (2000), Plant J., 24, 797-804.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.85 microsome
-
 Catharanthus roseus
-
-
1.14.19.62 microsome
-
 Catharanthus roseus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.62 loganin + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.85 Catharanthus roseus
-
-
-
1.14.19.62 Catharanthus roseus Q05047 L.D. Don, line CP3a, Madagascar periwinkle
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.19.62 loganin + [reduced NADPH-hemoprotein reductase] + O2 = secologanin + [oxidized NADPH-hemoprotein reductase] + 2 H2O epidermis-specific expression in immature leaves Catharanthus roseus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.85 cell culture
-
 Catharanthus roseus
-
1.14.19.62 cell suspension culture
-
 Catharanthus roseus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.85 7-deoxyloganin + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus loganin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.62 loganin + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus secologanin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.62 additional information no substrates: geraniol, nerol, flavonoids, cinnamic acid, lauric acid Catharanthus roseus ?
-
 ?
1.14.19.62 additional information loganin but not 7-deoxyloganin substrate for CYP72A1 expressed in Escherichia coli Catharanthus roseus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.62 CYP72A1 member of the P450 family CYP72 Catharanthus roseus