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Literature summary extracted from

  • Jeffcoat, R.; Brawn, P.R.; Safford, R.; James, A.T.
    Properties of rat liver microsomal stearoyl-coenzyme A desaturase (1977), Biochem. J., 161, 431-437.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.1 bovine serum albumin stimulates activity in the microsomal fraction Rattus norvegicus
1.14.19.1 cytochrome b5 reductase NADH-specific, required, EC 1.6.2.2 Rattus norvegicus
1.14.19.1 protein basic cytoplasmic protein from rat liver stimulates activity in crude extract, no activity of partially purified enzyme Rattus norvegicus
1.14.19.1 stearoyl-CoA-binding protein stimulates activity in the crude microsomal fraction Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 endoplasmic reticulum bound Rattus norvegicus 5783
-
1.14.19.1 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Rattus norvegicus
-
 Colworth-Wistar, male
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.19.1 partially Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.19.1 0.0315
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 additional information specific for C14-C19 fatty acyl-CoA substrates Rattus norvegicus ?
-
 ?
1.14.19.1 myristoyl-CoA + AH2 + O2
-
 Rattus norvegicus ?
-
 ?
1.14.19.1 nonadecanoyl-CoA + NADH + O2
-
 Rattus norvegicus ?
-
 ?
1.14.19.1 palmitoyl-CoA + NADH + O2
-
 Rattus norvegicus palmitoleoyl-CoA + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + O2 maximal activity Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.19.1 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.19.1 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 cytochrome b5 required Rattus norvegicus
1.14.19.1 NADH
-
 Rattus norvegicus