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Literature summary extracted from
- Terminal enzyme of stearoyl-CoA desaturation from chicken liver (1981), Methods Enzymol., 71, 252-258.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | cytochrome b5 reductase | flavoprotein | Gallus gallus |
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.14.19.1 | 50% loss of activity caused by repeated freezing and thawing | Gallus gallus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | 2,3-Butanedione | reversible | Gallus gallus |  |
| 1.14.19.1 | azide | - |
Gallus gallus | |
| 1.14.19.1 | CN- | - |
Gallus gallus | |
| 1.14.19.1 | Cu2+ | and its acid chelates | Gallus gallus | |
| 1.14.19.1 | decanoyl-CoA | competitive inhibitor | Gallus gallus | |
| 1.14.19.1 | dodecanoyl-CoA | competitive inhibitor | Gallus gallus | |
| 1.14.19.1 | p-chloromercuribenzoate | a sulfonate, reversed by beta-mercaptoethanol | Gallus gallus | |
| 1.14.19.1 | Tetranitromethane | - |
Gallus gallus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.1 | microsome | membrane bound | Gallus gallus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | Cu2+ | - |
Gallus gallus | |
| 1.14.19.1 | Fe2+ | - |
Gallus gallus | |
| 1.14.19.1 | Zn2+ | - |
Gallus gallus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.1 | 33600 | - |
x * 33600, SDS-PAGE | Gallus gallus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | stearoyl-CoA + AH2 + O2 | Gallus gallus | - |
oleoyl-CoA + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | Gallus gallus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.19.1 | several extractions besides ion-exchange and gel filtration | Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.1 | liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.1 | 0.11 | - |
- |
Gallus gallus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.14.19.1 | -70°C, stable at least 6 months | Gallus gallus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.1 | myristoyl-CoA + AH2 + O2 | 59% activity of the rate with stearoyl-CoA | Gallus gallus | ? | - |
? | |
| 1.14.19.1 | palmitoyl-CoA + AH2 + O2 | 62% activity of the rate with stearoyl-CoA | Gallus gallus | palmitoleoyl-CoA + A | - |
? | |
| 1.14.19.1 | stearoyl-CoA + AH2 + O2 | - |
Gallus gallus | oleoyl-CoA + A + H2O | - |
? | |
| 1.14.19.1 | stearoyl-CoA + NADH + O2 | - |
Gallus gallus | oleoyl-CoA + NAD+ + H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | ? | x * 33600, SDS-PAGE | Gallus gallus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.1 | DELTA9 terminal desaturase | - |
Gallus gallus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.1 | 7.2 | - |
assay at | Gallus gallus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.1 | cytochrome b5 | hemoprotein | Gallus gallus | |
| 1.14.19.1 | NADH | - |
Gallus gallus | |
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