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Literature summary extracted from

  • Cardemil, E.; Jabalquinto, A.M.
    Mevalonate 5-pyrophosphate decarboxylase from chicken liver (1985), Methods Enzymol., 110, 86-92.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.33 adenosine 5'-O-(3-thiotriphosphate)
-
 Gallus gallus
4.1.1.33 citrate
-
 Gallus gallus
4.1.1.33 Phthalate
-
 Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.33 0.0141
-
 5-diphosphomevalonate
-
 Gallus gallus
4.1.1.33 0.504
-
 ATP
-
 Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.33 Mg2+ divalent cation required, Mg2+ and Mn2+ being most effective Gallus gallus
4.1.1.33 Mn2+ divalent cation required, Mg2+ and Mn2+ being most effective Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.33 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.33
-
 Gallus gallus

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.33 ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2 sequential mechanism Gallus gallus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.33 liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.33 additional information
-
-
 Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.33 ATP + 5-diphosphomevalonate high specificity for ATP Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.33 4.5 7
-
 Gallus gallus