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Literature summary extracted from

  • Marutzky, R.; Flossdorf, J.; Kula, M.R.
    ATP-analogue as substrates for leucyl-TRNA synthetase from Escherichia coli MRE 600 (1976), Nucleic Acids Res., 3, 2067-2077.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.4 2'-dATP
-
 Escherichia coli
6.1.1.4 3'-Amino-3'-deoxy adenosine 5'-triphosphate
-
 Escherichia coli
6.1.1.4 6-dimethylaminopurine riboside 5'-triphosphate
-
 Escherichia coli
6.1.1.4 6-mercaptopurine riboside 5'-triphosphate
-
 Escherichia coli
6.1.1.4 6-methylaminopurine riboside 5'-triphosphate
-
 Escherichia coli
6.1.1.4 adenine arabinoside 5'-triphosphate
-
 Escherichia coli
6.1.1.4 adenosine
-
 Escherichia coli
6.1.1.4 adenyl(alpha,beta-methylene)triphosphonate
-
 Escherichia coli
6.1.1.4 adenylyl(beta,gamma-imido)triphosphonate
-
 Escherichia coli
6.1.1.4 adenylyl(beta,gamma-methylene)diphosphonate
-
 Escherichia coli
6.1.1.4 ADP
-
 Escherichia coli
6.1.1.4 AMP
-
 Escherichia coli
6.1.1.4 ITP
-
 Escherichia coli
6.1.1.4 Purine riboside 5'-triphosphate
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.4 0.045
-
 3'-dATP
-
 Escherichia coli
6.1.1.4 0.05
-
 L-Leu adenylyl (beta,gamma-imido)diphosphonate Escherichia coli
6.1.1.4 0.055
-
 adenosine 5'-O-(3-thiotriphosphate)
-
 Escherichia coli
6.1.1.4 0.065
-
 tubercidin 5'-triphosphate
-
 Escherichia coli
6.1.1.4 0.07
-
 8-Methylaminoadenosine 5'-triphosphate
-
 Escherichia coli
6.1.1.4 0.16
-
 8-azaadenosine 5'-triphosphate
-
 Escherichia coli
6.1.1.4 1
-
 8-bromoadenosine 5'-triphosphate
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.4 Escherichia coli
-
 MRE 600
-
6.1.1.4 Escherichia coli MRE 600
-
 MRE 600
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.4 3'-dATP + L-leucine + tRNALeu
-
 Escherichia coli 3'-dAMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 3'-dATP + L-leucine + tRNALeu
-
 Escherichia coli MRE 600 3'-dAMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 8-azaadenosine 5'-triphosphate + L-leucine + tRNALeu
-
 Escherichia coli 8-azaadenosine 5'-monophosphate + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 8-bromoadenosine 5'-triphosphate + L-leucine + tRNALeu
-
 Escherichia coli 8-bromoadenosine 5'-monophosphate + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 8-methylaminoadenosine 5'-triphosphate + L-leucine + tRNALeu
-
 Escherichia coli 8-methylaminoadenosine 5'-monophosphate + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 Adenosine 5'-O-(3-thio)triphosphate + L-leucine + tRNALeu
-
 Escherichia coli adenosine 5'-monophosphate + thiodiphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 Adenosine 5'-O-(3-thio)triphosphate + L-leucine + tRNALeu
-
 Escherichia coli MRE 600 adenosine 5'-monophosphate + thiodiphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 Adenylyl beta,gamma-imido diphosphonate + L-leucine + tRNALeu
-
 Escherichia coli Adenylic acid + imido-diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 Adenylyl beta,gamma-imido diphosphonate + L-leucine + tRNALeu
-
 Escherichia coli MRE 600 Adenylic acid + imido-diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Escherichia coli AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Escherichia coli MRE 600 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 tubercidin 5'-triphosphate + L-leucine + tRNALeu
-
 Escherichia coli tubercidin 5'-phosphate + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 tubercidin 5'-triphosphate + L-leucine + tRNALeu
-
 Escherichia coli MRE 600 tubercidin 5'-phosphate + diphosphate + L-leucyl-tRNALeu
-
 ?