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Literature summary extracted from
- Characterization of recombinant human aromatic L-amino acid decarboxylase expressed in COS cells (1990), J. Neurochem., 55, 1075-1078.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.28 | expression in COS cells | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.28 | 0.016 | - |
5-hydroxytryptophan | - |
Homo sapiens |  |
| 4.1.1.28 | 0.074 | - |
3,4-dihydroxyphenylalanine | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.28 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | 3,4-Dihydroxyphenylalanine | - |
Homo sapiens | 3-Hydroxytyramine + CO2 | - |
? | |
| 4.1.1.28 | 5-Hydroxytryptophan | - |
Homo sapiens | Serotonin + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.28 | 6.5 | - |
3,4-dihydroxyphenylalanine as substrate | Homo sapiens |
| 4.1.1.28 | 7 | 8.4 | 5-hydroxytryptophan as substrate | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.28 | pyridoxal 5'-phosphate | enhances activity | Homo sapiens | |
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Release 2023.1 (January 2023)
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