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Literature summary extracted from
- Orotidylate decarboxylase: insights into the catalytic mechanism from substrate specificity studies (1992), Biochemistry, 31, 12155-12161.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.23 | 5-Bromoorotidylate | - |
Saccharomyces cerevisiae |  |
| 4.1.1.23 | 5-Chloroorotidylate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 6-azauridine 5'-phosphate | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.0015 | - |
orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 0.02 | - |
4-Thioorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 0.03 | - |
5-Azaorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 0.056 | - |
5-Fluoroorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.23 | Zinc | no zinc detected | Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.23 | Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | 4-Thioorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | 4-Thiouridine 5'-phosphate + CO2 | - |
? | |
| 4.1.1.23 | 5-Azaorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | 5-Azauridine 5'-phosphate + CO2 | - |
? | |
| 4.1.1.23 | 5-Fluoroorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | 5-Fluorouridine 5'-phosphate + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | UMP + CO2 | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 5 | - |
5-Azaorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 9 | - |
4-Thioorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 19 | - |
orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.1.1.23 | 570 | - |
5-Fluoroorotidine 5'-phosphate | - |
Saccharomyces cerevisiae | |
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