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Literature summary extracted from

  • Brown, G.K.; Fox, R.M.; O'Sullivan, W.J.
    Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase (1975), J. Biol. Chem., 250, 7352-7358.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.1.1.23 conversion of the monomer to higher molecular weight forms is associated with increased stability Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.23 potassium phosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.23 0.0006
-
 orotidine 5'-phosphate tetrameric enzyme form Homo sapiens
4.1.1.23 0.003
-
 orotidine 5'-phosphate dimeric enzyme form Homo sapiens
4.1.1.23 0.025
-
 orotidine 5'-phosphate monomeric enzyme form Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.23 62000
-
 monomeric enzyme form, gel filtration Homo sapiens
4.1.1.23 115000
-
 dimeric enzyme form, gel filtration Homo sapiens
4.1.1.23 250000
-
 tetrameric enzyme form, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.23 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.23 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.23 0.0017
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
4.1.1.23 -15°C, storage of the high molecular weight forms in presence of 0.15 mM oxipurinol prevents the spontaneous dissociation which occures when these forms are stored in 50 mM potassium phosphate, pH 7.4 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate
-
 Homo sapiens UMP + CO2
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.23 55
-
 1 min: 60% loss of the activity of the monomeric form, 10% loss of activity of the tetrameric form Homo sapiens