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Literature summary extracted from
- Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of six biosynthetic enzymes (1973), Biochemistry, 12, 4039-4051.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.23 | 6-azauridine 5'-phosphate | - |
Mus musculus |  |
| 4.1.1.23 | UMP | product inhibition | Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.008 | 0.009 | orotidine 5'-phosphate | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.1.23 | additional information | - |
Mus musculus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 105000 | 115000 | bifunctional enzyme that contains activities of EC 2.4.2.10 and EC 4.1.1.23, sucrose density gradient centrifugation with 30% dimethyl sulfoxide and 5% glycerol | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | Orotidine 5'-phosphate | Mus musculus | required for the biosynthesis of uridylic acid | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.23 | Mus musculus | - |
bifunctional UMP synthase contains activities of EC 2.4.2.10 and EC 4.1.1.23 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.23 | Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Mus musculus | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | required for the biosynthesis of uridylic acid | Mus musculus | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 6.8 | - |
- |
Mus musculus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 6 | 8 | about 50% of maximal acticity at pH 6.0 and 8.0 | Mus musculus |
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