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Literature summary extracted from

  • Kamath, A.V.; Vaaler, G.L.; Snell, E.E.
    Pyridoxal phosphate-dependent histidine decarboxylases: Cloning, sequencing, and expression of genes from Klebsiella planticola and Enterobacter aerogenes and properties of the overexpressed enzymes (1991), J. Biol. Chem., 266, 9432-9437.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 expression in Escherichia coli Klebsiella aerogenes
4.1.1.22 expression in Escherichia coli Raoultella planticola

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 2.5
-
 L-His
-
 Raoultella planticola
4.1.1.22 2.6
-
 L-His
-
 Klebsiella aerogenes

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Klebsiella aerogenes
-
-
-
4.1.1.22 Raoultella planticola
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 80.5
-
-
 Raoultella planticola
4.1.1.22 153
-
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-His
-
 Klebsiella aerogenes Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Raoultella planticola Histamine + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.5
-
-
 Klebsiella aerogenes
4.1.1.22 6.5
-
-
 Raoultella planticola

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate contains 1 mol of pyridoxal 5'-phosphate per mol of subunit Klebsiella aerogenes
4.1.1.22 pyridoxal 5'-phosphate contains 1 mol of pyridoxal 5'-phosphate per mol of subunit Raoultella planticola