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Literature summary extracted from

  • Tanase, S.; Guirard, B.M.; Snell, E.E.
    Purification and properties of a pyridoxal 5'-phosphate-dependent histidine decarboxylase from Morganella morganii AM-15 (1985), J. Biol. Chem., 260, 6738-6746.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 2-Hydrazino-3-(4-imidazolyl)propionic acid
-
 Morganella morganii
4.1.1.22 alpha-Fluoromethylhistidine irreversible Morganella morganii
4.1.1.22 alpha-Methylhistidine
-
 Morganella morganii
4.1.1.22 dithiothreitol
-
 Morganella morganii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.22 1.2
-
 L-His pH 6.5-6.7 Morganella morganii
4.1.1.22 5.8
-
 1-methyl-DL-histidine
-
 Morganella morganii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 43000
-
 4 * 43000, SDS-PAGE Morganella morganii
4.1.1.22 113400
-
 gel filtration Morganella morganii
4.1.1.22 170000
-
 gel filtration Morganella morganii

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Morganella morganii
-
-
-
4.1.1.22 Morganella morganii AM-15
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Morganella morganii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 1-methyl-DL-histidine
-
 Morganella morganii 1-methylhistamine + CO2
-
 ?
4.1.1.22 1-methyl-DL-histidine
-
 Morganella morganii AM-15 1-methylhistamine + CO2
-
 ?
4.1.1.22 beta-(Pyridyl-2)-Ala
-
 Morganella morganii ?
-
 ?
4.1.1.22 beta-(Pyridyl-2)-Ala
-
 Morganella morganii AM-15 ?
-
 ?
4.1.1.22 L-His
-
 Morganella morganii Histamine + CO2
-
 ?
4.1.1.22 L-His
-
 Morganella morganii AM-15 Histamine + CO2
-
 ?
4.1.1.22 Npi-Methylhistidine
-
 Morganella morganii ?
-
 ?
4.1.1.22 Npi-Methylhistidine
-
 Morganella morganii AM-15 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 tetramer 4 * 43000, SDS-PAGE Morganella morganii

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.22 40
-
 not stable beyond 40°C Morganella morganii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.22 6.5
-
-
 Morganella morganii

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate the enzyme binds 4 pyridoxal 5'-phosphate per tetramer Morganella morganii