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Literature summary extracted from

  • Chang, G.W.; Snell, E.E.
    Histidine decarboxylase (Lactobacillus 30a) (1971), Methods Enzymol., 17B, 663-667.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 pyruvate contains several functionally essential pyruvate residues, covalently bound through an amide linkage to a Phe residue of the peptide chain. The free carbonyl group of these pyruvate residues undergoes Schiff base formation with His as part of the catalytic process Lactobacillus sp.

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.22
-
 Lactobacillus sp.

General Stability

EC Number General Stability Organism
4.1.1.22 inactivated by freezing and thawing Lactobacillus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.22 imidazole competitively inhibited Lactobacillus sp.
4.1.1.22 KCN non-competitive Lactobacillus sp.
4.1.1.22 PCMB
-
 Lactobacillus sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 9000
-
 x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.
4.1.1.22 29700
-
 x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.
4.1.1.22 190000
-
-
 Lactobacillus sp.

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Lactobacillus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.22
-
 Lactobacillus sp.

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.22 69
-
-
 Lactobacillus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 1-Methylhistidine very poor substrate Lactobacillus sp. 1-Methylhistamine
-
 ?
4.1.1.22 2-Thiolhistidine very poor substrate Lactobacillus sp. 1-Thiolhistamine
-
 ?
4.1.1.22 3-Methylhistidine very poor substrate Lactobacillus sp. 2-Methylhistamine
-
 ?
4.1.1.22 beta-(1,2,4-Triazole-3)-Ala very poor substrate Lactobacillus sp. ?
-
 ?
4.1.1.22 beta-(Pyridyl-2)-Ala very poor substrate Lactobacillus sp. ?
-
 ?
4.1.1.22 beta-(Thiazole-2)-Ala very poor substrate Lactobacillus sp. ?
-
 ?
4.1.1.22 L-His
-
 Lactobacillus sp. Histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 ? x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.