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Literature summary extracted from

  • Yeh, P.; Sicard, A.M.; Sinskey, A.J.
    General organization of the genes specifically involved in the diaminopimelate-lysine biosynthetic pathway of Corynebacterium glutamicum (1988), Mol. Gen. Genet., 212, 105-111.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.16
-
 Corynebacterium glutamicum
4.1.1.20 expression in Escherichia coli Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH Corynebacterium glutamicum
-
 meso-2,6-diaminoheptanedioate + H2O + NADP+
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH Corynebacterium glutamicum AS019
-
 meso-2,6-diaminoheptanedioate + H2O + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.16 Corynebacterium glutamicum
-
-
-
1.4.1.16 Corynebacterium glutamicum AS019
-
-
-
4.1.1.20 Corynebacterium glutamicum
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.1.16 0.13
-
 strain AS019 transformed with plasmid harboring cloned gene Corynebacterium glutamicum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Corynebacterium glutamicum meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H
-
 Corynebacterium glutamicum AS019 meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH
-
 Corynebacterium glutamicum meso-2,6-diaminoheptanedioate + H2O + NADP+
-
 r
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NADPH
-
 Corynebacterium glutamicum AS019 meso-2,6-diaminoheptanedioate + H2O + NADP+
-
 r
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Corynebacterium glutamicum L-Lysine + CO2
-
 ?
4.1.1.20 meso-2,6-Diaminoheptanedioate
-
 Corynebacterium glutamicum AS019 L-Lysine + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
 Corynebacterium glutamicum