BRENDA - Enzyme Database

Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain

Li, G.; Regunathan, S.; Reis, D.J.; Ann. N. Y. Acad. Sci. 763, 325-329 (1995)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.19
L-Gln
-
Rattus norvegicus
4.1.1.19
L-Lys
-
Rattus norvegicus
4.1.1.19
NG-methylarginine
-
Rattus norvegicus
4.1.1.19
NG-Nitroarginine
-
Rattus norvegicus
4.1.1.19
Orn
L-Orn
Rattus norvegicus
4.1.1.19
putrescine
-
Rattus norvegicus
4.1.1.19
spermidine
-
Rattus norvegicus
4.1.1.19
spermine
-
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.1.1.19
0.75
-
L-Arg
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.1.19
mitochondrion
highly if not exclusively associated with mitochondrial membrane
Rattus norvegicus
5739
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.1.19
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.1.1.19
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.19
L-arginine
-
4097
Rattus norvegicus
agmatine + CO2
-
4097
Rattus norvegicus
-
4.1.1.19
L-Orn
-
4097
Rattus norvegicus
?
-
-
-
-
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.1.1.19
30
-
-
Rattus norvegicus
Temperature Range [°C]
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
4.1.1.19
30
37
30°C: maximal activity, 37°C: about 35% of maximal activity
Rattus norvegicus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.1.1.19
8.3
-
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.19
L-Gln
-
Rattus norvegicus
4.1.1.19
L-Lys
-
Rattus norvegicus
4.1.1.19
NG-methylarginine
-
Rattus norvegicus
4.1.1.19
NG-Nitroarginine
-
Rattus norvegicus
4.1.1.19
Orn
L-Orn
Rattus norvegicus
4.1.1.19
putrescine
-
Rattus norvegicus
4.1.1.19
spermidine
-
Rattus norvegicus
4.1.1.19
spermine
-
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
4.1.1.19
0.75
-
L-Arg
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.1.19
mitochondrion
highly if not exclusively associated with mitochondrial membrane
Rattus norvegicus
5739
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.1.1.19
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.19
L-arginine
-
4097
Rattus norvegicus
agmatine + CO2
-
4097
Rattus norvegicus
-
4.1.1.19
L-Orn
-
4097
Rattus norvegicus
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.1.1.19
30
-
-
Rattus norvegicus
Temperature Range [°C] (protein specific)
EC Number
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
4.1.1.19
30
37
30°C: maximal activity, 37°C: about 35% of maximal activity
Rattus norvegicus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
4.1.1.19
8.3
-
-
Rattus norvegicus