BRENDA - Enzyme Database

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells

Kierszenbaum, F.; Wirth, J.J.; McCann, P.P.; Sjoerdsma, A.; Proc. Natl. Acad. Sci. USA 84, 4278-4282 (1987)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.19
(E)-alpha-Monofluoromethyl-3-4-dehydroarginine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
4.1.1.19
DL-alpha-difluoromethylarginine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
4.1.1.19
Monofluoromethylagmatine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.1.19
Trypanosoma cruzi
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.19
L-arginine
-
4087
Trypanosoma cruzi
agmatine + CO2
-
4087
Trypanosoma cruzi
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.1.19
(E)-alpha-Monofluoromethyl-3-4-dehydroarginine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
4.1.1.19
DL-alpha-difluoromethylarginine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
4.1.1.19
Monofluoromethylagmatine
irreversible inhibitor may have a potential application in chemotherapy against Trypanosoma cruzi infection
Trypanosoma cruzi
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.1.19
L-arginine
-
4087
Trypanosoma cruzi
agmatine + CO2
-
4087
Trypanosoma cruzi
-