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Literature summary extracted from
- L-Glutamate decarboxylase from bacteria (1985), Methods Enzymol., 113, 11-16.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.15 | Br- | activates | Escherichia coli |  |
| 4.1.1.15 | Cl- | activates | Escherichia coli | |
| 4.1.1.15 | F- | activates | Escherichia coli | |
| 4.1.1.15 | I- | activates | Escherichia coli | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.15 | Cycloglutamates | - |
Escherichia coli | |
| 4.1.1.15 | Substituted dicarboxylic acids | - |
Escherichia coli |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.15 | 0.5 | 1.9 | L-Glu | at pH 4.6 | Escherichia coli | |
| 4.1.1.15 | 0.6 | - |
L-Glu | - |
Clostridium perfringens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 50000 | - |
6 * 50000 | Escherichia coli |
| 4.1.1.15 | 290000 | - |
- |
Clostridium perfringens |
| 4.1.1.15 | 310000 | - |
equilibrium sedimentation | Escherichia coli |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.15 | Clostridium perfringens | - |
- |
- |
| 4.1.1.15 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.15 | - |
Escherichia coli |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 67.9 | - |
- |
Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.15 | L-alpha-Methylglutamate | - |
Escherichia coli | ? | - |
? | |
| 4.1.1.15 | L-Glu | - |
Escherichia coli | 4-Aminobutanoate + CO2 | - |
? | |
| 4.1.1.15 | L-Glu | - |
Clostridium perfringens | 4-Aminobutanoate + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.15 | hexamer | 6 * 50000 | Escherichia coli |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.15 | 4 | 4.5 | - |
Escherichia coli |
| 4.1.1.15 | 4.7 | - |
- |
Clostridium perfringens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.15 | pyridoxal 5'-phosphate | one molecule of pyridoxal 5'-phosphate is covalently bound to a lysyl residue | Escherichia coli | |
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Release 2023.1 (January 2023)
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