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Literature summary extracted from

  • Flohe, L.
    The selenoprotein glutathione peroxidase (1989), Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York, , 643-731.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.9 additional information not: ophthalmic acid aves
1.11.1.9 additional information not: ophthalmic acid Chondrichthyes
1.11.1.9 additional information not: ophthalmic acid Mammalia
1.11.1.9 additional information not: ophthalmic acid Testudines
1.11.1.9 O2-
-
 aves
1.11.1.9 O2-
-
 Chondrichthyes
1.11.1.9 O2-
-
 Mammalia
1.11.1.9 O2-
-
 Testudines
1.11.1.9 Polyvalent anions e.g. phosphate, sulfate, maleate aves
1.11.1.9 Polyvalent anions e.g. phosphate, sulfate, maleate Chondrichthyes
1.11.1.9 Polyvalent anions e.g. phosphate, sulfate, maleate Mammalia
1.11.1.9 Polyvalent anions e.g. phosphate, sulfate, maleate Testudines

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.9 cytosol
-
 Mammalia 5829
-
1.11.1.9 mitochondrial matrix 25% of activity Mammalia 5759
-
1.11.1.9 additional information not in peroxisomes Mammalia
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.11.1.9 selenium selenocysteine Mammalia
1.11.1.9 selenium selenocysteine Chondrichthyes
1.11.1.9 selenium selenocysteine aves
1.11.1.9 selenium selenocysteine Testudines

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.9 glutathione + ROOH Mammalia broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH Chondrichthyes broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH aves broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH Testudines broad specificity for hydroperoxides glutathione disulfide + ROH + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 aves
-
-
-
1.11.1.9 Chondrichthyes
-
-
-
1.11.1.9 Mammalia
-
-
-
1.11.1.9 no activity in plants
-
-
-
1.11.1.9 Testudines
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.11.1.9 2 glutathione + H2O2 = glutathione disulfide + 2 H2O mechanism Mammalia
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 glutathione + ROOH broad specificity for hydroperoxides Mammalia glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH broad specificity for hydroperoxides Chondrichthyes glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH broad specificity for hydroperoxides aves glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 glutathione + ROOH broad specificity for hydroperoxides Testudines glutathione disulfide + ROH + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.9 homotetramer
-
 Mammalia