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Literature summary extracted from
- Cysteamine dioxygenase (1987), Methods Enzymol., 143, 410-415.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.19 | 1,3-dithiopropane | - |
Sus scrofa |  |
| 1.13.11.19 | 1,4-dithiobutane | - |
Sus scrofa | |
| 1.13.11.19 | mercaptoethylguanidine | noncompetitive to cysteamine | Sus scrofa | |
| 1.13.11.19 | pantetheine | - |
Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.19 | 0.001 | - |
cysteamine | - |
Sus scrofa | |
| 1.13.11.19 | 0.1 | - |
O2 | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.13.11.19 | cytosol | - |
Sus scrofa | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.19 | 64000 | - |
2 * 64000, SDS-PAGE | Sus scrofa |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.19 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.19 | liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.19 | 2.8 | - |
- |
Sus scrofa |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.13.11.19 | -20°C, up to 3 years | Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.19 | cysteamine + O2 | - |
Sus scrofa | hypotaurine | - |
? | |
| 1.13.11.19 | additional information | synthetic analogs of cysteamine oxidized: piperazinylcysteamine, N,N-dimethylcysteamine, trimethyl(2-mercaptoethyl)ammonium chloride, 2-mercaptoethanol, cysteine methyl ester | Sus scrofa | additional information | - |
? | |
| 1.13.11.19 | pantetheine + O2 | oxidized at less than 3% of the cysteamine-dependent rate | Sus scrofa | pantothenate + cysteamine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.13.11.19 | dimer | 2 * 64000, SDS-PAGE | Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.19 | 37 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.19 | 7.8 | - |
assay at | Sus scrofa |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.13.11.19 | 0.007 | - |
mercaptoethylguanidine | - |
Sus scrofa | |
| 1.13.11.19 | 0.02 | - |
1,3-dithiopropane | - |
Sus scrofa | |
| 1.13.11.19 | 0.02 | - |
1,4-dithiobutane | - |
Sus scrofa | |
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Release 2023.1 (January 2023)
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