EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.22 | 4,16-androstadien-3-one | - |
Sus scrofa | |
1.3.1.22 | finasteride | - |
Homo sapiens | |
1.3.1.22 | LY306089 | a non steroid, non-competitive inhibitor of type I 5alpha-reductase in DU145 cells | Homo sapiens | |
1.3.1.22 | MK434 | - |
Sus scrofa | |
1.3.1.22 | progesterone | competitive | Homo sapiens | |
1.3.1.22 | progesterone | competitive | Sus scrofa | |
1.3.1.22 | SKF105657 | a steroidal type II 5alpha-reductase specific inhibitor | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.008 | - |
testosterone | - |
Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.22 | microsome | - |
Homo sapiens | - |
- |
1.3.1.22 | microsome | - |
Sus scrofa | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.22 | Homo sapiens | - |
- |
- |
1.3.1.22 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.22 | testis | - |
Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.22 | testosterone + NADPH + H+ | - |
Sus scrofa | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.22 | 5.7 | - |
in testis microsomes of 5 month-old animals | Sus scrofa |
1.3.1.22 | 6.3 | - |
in testis microsomes of 6 month-old animals | Sus scrofa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.000004 | - |
LY306089 | - |
Homo sapiens | |
1.3.1.22 | 0.00086 | - |
progesterone | - |
Sus scrofa | |
1.3.1.22 | 0.0031 | - |
MK434 | - |
Sus scrofa | |
1.3.1.22 | 0.0049 | - |
4,16-androstadien-3-one | - |
Sus scrofa |