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Literature summary extracted from

  • Delos, S.; Iehle, C.; Martin, M.; Raynaud, J.P.
    Inhibition of the activity of basic 5alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells (1994), J. Steroid Biochem. Mol. Biol., 48, 347-352.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 4-methyl-4-azasteroids 4-MA is a 90-fold more potent inhibitor than finasteride in the DU 145 cell-line; competitive Homo sapiens
1.3.1.22 4-methyl-4-azasteroids competitive Spodoptera frugiperda
1.3.1.22 4-methyl-azasteroid
-
 Spodoptera frugiperda
1.3.1.22 finasteride
-
 Homo sapiens
1.3.1.22 finasteride
-
 Spodoptera frugiperda

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-
1.3.1.22 Spodoptera frugiperda
-
 Sf 9 cell-line
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 prostate gland studies in DU 145 cells, a human cell-line of low androgen sensitivity derived from a cerebral metastasis of an ephithelial prostate cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 androstenedione + NADPH + H+
-
 Homo sapiens 5alpha-androstan-3,17-dione + NADP+
-
 ?
1.3.1.22 deoxycorticosterone + NADPH
-
 Homo sapiens 21-hydroxy-5alpha-pregnan-3,20-dione
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.22 0.0000084
-
 4-methyl-azasteroid
-
 Spodoptera frugiperda
1.3.1.22 0.00033
-
 finasteride
-
 Spodoptera frugiperda