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Literature summary extracted from

  • Jurman, M.E.; Erulkar, S.D.; Krieger, N.R.
    Testosterone 5alpha-reductase in spinal cord of Xenopus laevis (1982), J. Neurochem., 38, 657-661.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.002
-
 testosterone
-
 Xenopus laevis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Xenopus laevis
-
 South African clawed frog
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 spinal cord
-
 Xenopus laevis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Xenopus laevis 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Xenopus laevis 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.22 27
-
-
 Xenopus laevis

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.3.1.22 21 37 21°C: about 50% of activity maximum, 37°C: about 70% of activity maximum Xenopus laevis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 7.4
-
-
 Xenopus laevis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.22 6.5 8.6 half maximal activity at pH 6.5 and 8.6 Xenopus laevis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Xenopus laevis