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Literature summary extracted from

  • Shefer, S.; Hauser, S.; Mosbach, E.H.
    Studies on the biosynthesis of 5alpha-cholestan-3beta-ol 1.Cholestenone of rat liver (1965), J. Biol. Chem., 241, 946-952.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 17alpha-methyltestosterone
-
 Rattus norvegicus
1.3.1.22 5beta-cholestan-3-one
-
 Rattus norvegicus
1.3.1.22 androst-4-en-3,17-dione
-
 Rattus norvegicus
1.3.1.22 cholest-5-en-3-one
-
 Rattus norvegicus
1.3.1.22 cholestanone
-
 Rattus norvegicus
1.3.1.22 p-chloromercuribenzoate
-
 Rattus norvegicus
1.3.1.22 testosterone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Rattus norvegicus
-
-
1.3.1.22 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 More microsomal cholest-4-en-3-one 5alpha-reductase is not identical with microsomal DELTA4-3-ketosteroid 5alpha-reductase Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 7.3 7.6
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 additional information NADH: no activity Rattus norvegicus
1.3.1.22 additional information absolute requirement for NADPH in rat liver Rattus norvegicus
1.3.1.22 additional information absolute requirement for NADPH in rat epididymis Rattus norvegicus
1.3.1.22 NADPH absolute requirement for NADPH Rattus norvegicus