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Literature summary extracted from

  • Koninckx, P.; Verhoeven, G.; Heyns, W.; De Moore, P.
    Biochemical characterization of the NADPH: 4-ene-3-ketosteroid 5alpha-oxidoreductase in rat ovarian suspension cultures (1979), J. Steroid Biochem., 10, 325-333.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 4-Ene-3-keto-steroids 17beta-estradiol in high concentrations functions as an uncompetitive inhibitor Rattus norvegicus
1.3.1.22 estradiol-17beta high concentration Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.00057
-
 17-epitestosterone in homogenates Rattus norvegicus
1.3.1.22 0.00078
-
 17-epitestosterone in living cells Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 ovary
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 17-epitestosterone + NADPH
-
 Rattus norvegicus ?
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 7
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.3.1.22 4.5 9 pH .5: about 30% of activity maximum, pH 9.0: about 20% of activity maximum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Rattus norvegicus