Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Moore, R.J.; Wilson, J.D.
    Reduced nicotinamide adenine dinucleotide phosphate delta4-3-ketosteroid 5alpha-oxidoreductase (rat ventral prostate) (1975), Methods Enzymol., 36A, 466-474.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 Ca2+ 1 mM: less than 20% inhibition Rattus norvegicus
1.3.1.22 Cd2+ 1 mM: less than 20% inhibition Rattus norvegicus
1.3.1.22 Cu2+ 1 mM Rattus norvegicus
1.3.1.22 Mn2+ 1 mM: less than 20% inhibition Rattus norvegicus
1.3.1.22 Zn2+ 1 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.032
-
testosterone
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 membrane
-
Rattus norvegicus 16020
-
1.3.1.22 nuclear envelope
-
Rattus norvegicus 5635
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.22
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 epididymis
-
Rattus norvegicus
-
1.3.1.22 genitalia external Rattus norvegicus
-
1.3.1.22 additional information highest activity in organs of acessory reproduction and in liver Rattus norvegicus
-
1.3.1.22 preputial gland
-
Rattus norvegicus
-
1.3.1.22 prostate gland ventral Rattus norvegicus
-
1.3.1.22 seminal vesicle
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.22 additional information
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
1.3.1.22 -20°C, 6 months Rattus norvegicus
1.3.1.22 4°C, 2 days, 50% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 17alpha-hydroxyprogesterone + NADPH
-
Rattus norvegicus 17alpha-hydroxy-5alpha-pregnan-3,20-dione + NADP+
-
ir
1.3.1.22 20-alpha-hydroxypregn-4-ene-3one + NADPH
-
Rattus norvegicus 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+
-
ir
1.3.1.22 androstenediol + NADPH
-
Rattus norvegicus 5alpha-androstan-3beta,17beta-diol + NADP+
-
ir
1.3.1.22 androstenedione + NADPH + H+
-
Rattus norvegicus 5alpha-androstan-3,17-dione + NADP+
-
ir
1.3.1.22 cholest-4-en-3-one + NADPH mammalian enzymes: no reverse reaction, first step in reverse direction (enolization) occurs, but energy barrier for hydride abstraction is extremely high Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
ir
1.3.1.22 cortexolone + NADPH
-
Rattus norvegicus 17alpha,21-dihydroxy-5alpha-pregnan-3,20-dione + NADP+
-
ir
1.3.1.22 deoxycorticosterone + NADPH
-
Rattus norvegicus 21-hydroxy-5alpha-pregnan-3,20-dione
-
ir
1.3.1.22 epitestosterone + NADPH
-
Rattus norvegicus ?
-
ir
1.3.1.22 progesterone + NADPH + H+
-
Rattus norvegicus 5alpha-pregnan-3,20-dione + NADP+
-
ir
1.3.1.22 testosterone + NADPH + H+
-
Rattus norvegicus 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
ir

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.3.1.22 25
-
1 h stable Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 6.6
-
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 additional information
-
Rattus norvegicus
1.3.1.22 NADPH
-
Rattus norvegicus