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Literature summary extracted from

  • Brunori, M.; Antonini, G.; Malatesta, F.; Sarti, P.; Wilson, M.T.
    Structure and function of cytochrome oxidase: a second look (1987), Adv. Inorg. Biochem., 7, 93-154.
    View publication on PubMed

General Stability

EC Number General Stability Organism
7.1.1.9 depletion of lipids causes inactivation Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 CO competitive vs. O2 Bacteria
7.1.1.9 CO competitive vs. O2 Bos taurus
7.1.1.9 CO competitive vs. O2 eukaryota

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.9 0.001
-
 O2
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.1.9 Cu
-
 Bacteria
7.1.1.9 Cu
-
 eukaryota
7.1.1.9 Cu
-
 Bos taurus
7.1.1.9 Fe
-
 Bacteria
7.1.1.9 Fe
-
 eukaryota
7.1.1.9 Fe
-
 Bos taurus
7.1.1.9 Zn
-
 Bacteria
7.1.1.9 Zn
-
 eukaryota
7.1.1.9 Zn
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.1.1.9 5441
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 6244
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 6350
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 8480
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 9419
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 10068
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 10670
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 12436
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 17153
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 26049
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 29918
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 56993
-
 I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus
7.1.1.9 200000
-
 heart, monomeric enzyme, deoxycholate solubilized, hydrodynamic measurements Bos taurus
7.1.1.9 350000
-
 dimeric form, Triton X-100 solubilized, hydrodynamic measurements Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Bacteria
-
-
-
7.1.1.9 Bos taurus
-
-
-
7.1.1.9 eukaryota
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.1.1.9 phospholipoprotein
-
 eukaryota
7.1.1.9 phospholipoprotein
-
 Bos taurus

Renatured (Commentary)

EC Number Renatured (Comment) Organism
7.1.1.9 overview of methods for reconstitution eukaryota
7.1.1.9 reconstitution methods Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Bacteria ferricytochrome c + H2O
-
 r
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Bos taurus ferricytochrome c + H2O
-
 r

Subunits

EC Number Subunits Comment Organism
7.1.1.9 More
-
 eukaryota
7.1.1.9 More definitions of functional unit Bos taurus
7.1.1.9 oligomer
-
 Bacteria
7.1.1.9 oligomer
-
 eukaryota
7.1.1.9 oligomer I, II, III, IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, VIII, 1 * 56993 + 1 * 26049 + 1 * 29918 + 1 * 17153 + 1 * 12436 + 1 * 10670 + 1 * 9419 + 1 * 10068 + 1 * 8480 + 1 * 5441 + 1 * 6244 + 1 * 6350 + 1 * 4962, heart, 13 subunits, nomenclature system of subunits according to Kadenbach et. al, BRENDA reference 396096 (PubMed-ID 6303162), and literature cited therein, other nomenclature systems, amino acid sequences Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7.1.1.9 50 100 cytochrome c soluble enzyme, higher values for particulate enzyme eukaryota
7.1.1.9 50 100 ferrocytochrome c soluble enzyme, higher values for particulate enzyme Bacteria
7.1.1.9 50 100 ferrocytochrome c soluble enzyme, higher values for particulate enzyme Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.9 heme a
-
 Bacteria
7.1.1.9 heme a
-
 eukaryota
7.1.1.9 heme a
-
 Bos taurus
7.1.1.9 Heme a3
-
 Bacteria
7.1.1.9 Heme a3
-
 eukaryota
7.1.1.9 Heme a3
-
 Bos taurus