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Literature summary extracted from

  • DeFelice, M.; Lago, C.T.; Squires, C.H.; Calvo, J.M.
    Acetohydroxy acid synthase isoenzymes of Escherichia coli K12 and Salmonella typhimurium (1982), Ann. Microbiol., 133A, 251-256.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.6 Ile mild inhibition of isoenzyme I and III Escherichia coli
2.2.1.6 Ile inhibition of isoenzyme I, no inhibition of isoenzyme II Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 Leu no inhibition of isoenzyme I and III Escherichia coli
2.2.1.6 Leu inhibition of isoenzyme I, no inhibition of isoenzyme II Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 Val isoenzymes I and II are inhibited, isoenzyme II is not inhibited Escherichia coli
2.2.1.6 Val isoenzymes I and II are inhibited, isoenzyme II is not inhibited Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 pyruvate Salmonella enterica subsp. enterica serovar Typhimurium isoenzyme II is regulated by Leu, Ile and Val ?
-
 ?
2.2.1.6 pyruvate Escherichia coli isoenzyme II is regulated by Leu, Ile and Val ?
-
 ?
2.2.1.6 pyruvate Salmonella enterica subsp. enterica serovar Typhimurium isoenzyme II is regulated by Leu ?
-
 ?
2.2.1.6 pyruvate Escherichia coli isoenzyme II is regulated by Leu ?
-
 ?
2.2.1.6 pyruvate Salmonella enterica subsp. enterica serovar Typhimurium first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile ?
-
 ?
2.2.1.6 pyruvate Escherichia coli first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile ?
-
 ?
2.2.1.6 pyruvate Salmonella enterica subsp. enterica serovar Typhimurium isoenzyme I is regulated by Leu and Val ?
-
 ?
2.2.1.6 pyruvate Escherichia coli isoenzyme I is regulated by Leu and Val ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Escherichia coli
-
 K-12
-
2.2.1.6 Escherichia coli
-
 3 isoenzymes: I, II, and III
-
2.2.1.6 Escherichia coli
-
 isoenzyme I and III are expressed in wild type cells, isoenzyme II is cryptic
-
2.2.1.6 Salmonella enterica subsp. enterica serovar Typhimurium
-
 3 isoenzymes: I, II, and III
-
2.2.1.6 Salmonella enterica subsp. enterica serovar Typhimurium
-
 isoenzyme I and II are expressed in wild type cells, isoenzyme III is cryptic
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 pyruvate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate
-
 Escherichia coli 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate isoenzyme II is regulated by Leu, Ile and Val Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.2.1.6 pyruvate isoenzyme II is regulated by Leu, Ile and Val Escherichia coli ?
-
 ?
2.2.1.6 pyruvate isoenzyme II is regulated by Leu Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.2.1.6 pyruvate isoenzyme II is regulated by Leu Escherichia coli ?
-
 ?
2.2.1.6 pyruvate first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.2.1.6 pyruvate first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile Escherichia coli ?
-
 ?
2.2.1.6 pyruvate isoenzyme I is regulated by Leu and Val Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.2.1.6 pyruvate isoenzyme I is regulated by Leu and Val Escherichia coli ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.2.1.6 7
-
 isoenzyme I Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 7
-
 isoenzyme I Escherichia coli
2.2.1.6 8
-
 isoenzyme II Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 8
-
 isoenzyme II Escherichia coli
2.2.1.6 9
-
 isoenzyme III Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 9
-
 isoenzyme III Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.6 FAD partial requirement for isoenzyme III Salmonella enterica subsp. enterica serovar Typhimurium
2.2.1.6 FAD absolutly required for isoenzyme I and II, no requirement for isoenzyme III Escherichia coli