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Literature summary extracted from

  • Barak, Z.; Chipman, D.M.; Gollop, N.
    Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria (1987), J. Bacteriol., 169, 3750-3756.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.2.1.6 1
-
 pyruvate pH 7.6, isoenzyme AHAS I Escherichia coli
2.2.1.6 7
-
 pyruvate pH 7.6, isoenzyme AHAS III Escherichia coli
2.2.1.6 10.6
-
 pyruvate pH 7.6, isoenzyme AHAS II Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 pyruvate Salmonella enterica subsp. enterica serovar Typhimurium isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations ?
-
 ?
2.2.1.6 pyruvate Escherichia coli isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Escherichia coli
-
 3 isoenzymes: I, II, and III
-
2.2.1.6 Salmonella enterica subsp. enterica serovar Typhimurium
-
 3 isoenzymes: I, II, and III
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 pyruvate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate
-
 Escherichia coli 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.2.1.6 pyruvate isoenzyme AHAS I enables a bacterium to cope with poor carbon sources, which lead to low endogenous pyruvate concentrations Escherichia coli ?
-
 ?
2.2.1.6 pyruvate + 2-oxobutanoate isoenzyme I shows no product preference, isoenzymes II and III form acetohydroxybutanoate at 180fold and 60fold faster rates, respectively than acetolactate Salmonella enterica subsp. enterica serovar Typhimurium acetohydroxybutanoate
-
 ?
2.2.1.6 pyruvate + 2-oxobutanoate isoenzyme I shows no product preference, isoenzymes II and III form acetohydroxybutanoate at 180fold and 60fold faster rates, respectively than acetolactate Escherichia coli acetohydroxybutanoate
-
 ?