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Literature summary extracted from

  • Brady, F.O.; Monaco, M.E.; Forman, H.J.; Schutz, G.; Feigelson, P.
    On the role of copper in activation of and catalysis by tryptophan-2,3-dioxygenase (1972), J. Biol. Chem., 247, 7915-7922.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 Bathocuproinesulfonate competitive with respect to L-Trp and noncompetitive with respect to O2 Delftia acidovorans
1.13.11.52 diethyldithiocarbamate
-
 Delftia acidovorans
1.13.11.52 diethyldithiocarbamate
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.52 copper contains 2 gatom of copper per mol of enzyme Rattus norvegicus
1.13.11.52 copper contains 2 gatom of copper per mol of enzyme Delftia acidovorans

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Delftia acidovorans
-
-
-
1.13.11.52 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Delftia acidovorans

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.52 additional information
-
-
 Rattus norvegicus
1.13.11.52 additional information
-
-
 Delftia acidovorans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-Trp + O2
-
 Rattus norvegicus L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2
-
 Delftia acidovorans L-formylkynurenine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Delftia acidovorans
1.13.11.52 heme 2 mol of heme per tetramer Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.031
-
 Bathocuproinesulfonate
-
 Delftia acidovorans