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Literature summary extracted from
- The tryptophan 2,3-dioxygenase of the blowfly, Protophormia terrae-novae: partial purification and characterization (1976), Hoppe-Seyler's Z. Physiol. Chem., 357, 41-49.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.13.11.52 | unstable in purified state, if the substrate is omitted during the last step, the activity is lost entirely | Protophormia terraenovae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.13.11.52 | 3-hydroxykynurenine | 0.1 mM, weak inhibition amounting to about 30% | Protophormia terraenovae |  |
| 1.13.11.52 | CN- | 9.6 mM, 50% inhibition | Protophormia terraenovae | |
| 1.13.11.52 | Cu2+ | 0.005 mM, 50% inhibition | Protophormia terraenovae | |
| 1.13.11.52 | L-Trp | above 8 mM | Protophormia terraenovae | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.13.11.52 | cytosol | enzyme is confined to cytosol | Protophormia terraenovae | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.52 | 120000 | - |
gel filtration | Protophormia terraenovae |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | Protophormia terraenovae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.13.11.52 | - |
Protophormia terraenovae |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.13.11.52 | adult | - |
Protophormia terraenovae | - |
| 1.13.11.52 | larva | - |
Protophormia terraenovae | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.52 | additional information | - |
- |
Protophormia terraenovae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.13.11.52 | L-Trp + O2 | absolutely specific for L-Trp | Protophormia terraenovae | L-formylkynurenine | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.52 | 8.2 | - |
- |
Protophormia terraenovae |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.13.11.52 | 7 | 9.5 | pH 7.0: about 40% of maximal activity, pH 9.5: about 50% of maximal activity | Protophormia terraenovae |
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