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Literature summary extracted from

  • Ishimura, Y.; Makino, R.; Iizuka, T.
    Regulatory control and catalytic mechanisms of L-tryptophan 2,3-dioxygenase (pyrrolase) (1980), Adv. Enzyme Regul., 18, 291-302.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.52 167000
-
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-Trp + O2 Rattus norvegicus regulatory control L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2 Oryctolagus cuniculus regulatory control L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2 Pseudomonas sp. regulatory control L-formylkynurenine
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Oryctolagus cuniculus
-
-
-
1.13.11.52 Pseudomonas sp.
-
-
-
1.13.11.52 Rattus norvegicus
-
tryptophan 2,3-dioxygenase from liver
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-Trp + O2
-
Rattus norvegicus L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2
-
Oryctolagus cuniculus L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2
-
Pseudomonas sp. L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2 regulatory control Rattus norvegicus L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2 regulatory control Oryctolagus cuniculus L-formylkynurenine
-
?
1.13.11.52 L-Trp + O2 regulatory control Pseudomonas sp. L-formylkynurenine
-
?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 monomer
-
Oryctolagus cuniculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.52 additional information
-
additional information
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme 2 mol of heme per tetramer Rattus norvegicus
1.13.11.52 heme 2 mol of heme per tetramer Pseudomonas sp.
1.13.11.52 heme 1 mol of heme per mol of monomer Oryctolagus cuniculus