Literature summary extracted from

Terentis, A.C.; Thomas, S.R.; Takikawa, O.; Littlejohn, T.K.; Truscott, R.J.W.; Armstrong, R.S.; Yeh, S.R.; Stocker, R.
The heme environment of recombinant human indoleamine 2,3-dioxygenase: Structural properties and substrate-ligand interactions (2002), J. Biol. Chem., 277, 15788-15794.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.52	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.52	L-Trp + O2	-	Homo sapiens	L-formylkynurenine	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.13.11.52	heme	characterization of the heme environment, strong proximal Fe-His bond and strond H-bonding and/or steric interactions between L-Trp and dioxygen in the distal pocket are likely crucial for the enzymatic activity of the recombinant enzyme	Homo sapiens

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Release 2023.1 (January 2023)