Literature summary extracted from

Thomas, S.R.; Mohr, D.; Stocker, R.
Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes (1994), J. Biol. Chem., 269, 14457-14464.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.52	NO	-	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.13.11.52	cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.13.11.52	L-Trp + O2	Homo sapiens	initial enzyme of tryptophan degradation pathway	L-formylkynurenine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.52	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.52	mononuclear phagocyte	IFNgamma-primed	Homo sapiens	-
1.13.11.52	peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.52	L-Trp + O2	-	Homo sapiens	L-formylkynurenine	-	?
1.13.11.52	L-Trp + O2	initial enzyme of tryptophan degradation pathway	Homo sapiens	L-formylkynurenine	-	?

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Release 2023.1 (January 2023)