Literature summary extracted from

Salter, M.; Hazelwood, R.; Pogson, C.I.; Iyer, R.; Madge, D.J.
The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat (1995), Biochem. Pharmacol., 49, 1435-1442.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.52	(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.13.11.52	L-Trp + O2	Rattus norvegicus	key enzyme of tryptophan catabolism, importance as regulator of whole-body tryptophan catabolism and brain levels of tryptophan and serotonin	L-formylkynurenine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.52	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.52	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.52	L-Trp + O2	-	Rattus norvegicus	L-formylkynurenine	-	?
1.13.11.52	L-Trp + O2	key enzyme of tryptophan catabolism, importance as regulator of whole-body tryptophan catabolism and brain levels of tryptophan and serotonin	Rattus norvegicus	L-formylkynurenine	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.13.11.52	0.000051	-	(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole	-	Rattus norvegicus

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Release 2023.1 (January 2023)