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Literature summary extracted from

  • Yoshida, R.; Hayaishi, O.
    Overview: superoxygenase (1984), Methods Enzymol., 105, 61-70.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 superoxide the enzyme is inactive unless superoxide anion is present, the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 diethyldithiocarbamate 5 mM, markedly enhances activity Oryctolagus cuniculus
1.13.11.52 Superoxide dismutase
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.52 copper only trace amounts of copper Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-Trp + O2 Oryctolagus cuniculus a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon L-formylkynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Oryctolagus cuniculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.13.11.52 glycoprotein contains approximately 5% carbohydrate per weight Oryctolagus cuniculus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-Trp + O2 superoxide anion is required for the initiation of the reaction and the maintenance of the catalytic cycle during the steady state Oryctolagus cuniculus L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2 a dramatic and specific induction of the pulmonary enzyme by virus and lipopolysaccharide is mediated by interferon. The enzyme may play an important role in the inflammatory processes, immune responses, and/or the mode of action of interferon Oryctolagus cuniculus L-formylkynurenine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme the native ferric form of the enzyme binds to the superoxide anion to form the oxygenated enzyme Oryctolagus cuniculus
1.13.11.52 heme 0.8 mol of protoheme IX per mol of enzyme Oryctolagus cuniculus