Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Feigelson, P.; Brady, F.O.
    Heme-containing dioxygenases (1974), Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York, , 87-133.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 DL-4-fluorotryptophan
-
 Delftia acidovorans
1.13.11.52 DL-4-fluorotryptophan
-
 Rattus norvegicus
1.13.11.52 DL-4-methyltryptophan
-
 Delftia acidovorans
1.13.11.52 DL-4-methyltryptophan
-
 Rattus norvegicus
1.13.11.52 DL-5-fluorotryptophan
-
 Delftia acidovorans
1.13.11.52 DL-5-fluorotryptophan
-
 Rattus norvegicus
1.13.11.52 DL-5-Methyltryptophan
-
 Delftia acidovorans
1.13.11.52 DL-5-Methyltryptophan
-
 Rattus norvegicus
1.13.11.52 indole
-
 Delftia acidovorans
1.13.11.52 indole
-
 Rattus norvegicus
1.13.11.52 Indolepropionic acid
-
 Delftia acidovorans
1.13.11.52 Indolepropionic acid
-
 Rattus norvegicus
1.13.11.52 L-5-hydroxytryptophan
-
 Delftia acidovorans
1.13.11.52 L-5-hydroxytryptophan
-
 Rattus norvegicus
1.13.11.52 additional information no inhibition by D-5-hydroxytryptophan Delftia acidovorans
1.13.11.52 additional information no inhibition by D-5-hydroxytryptophan Rattus norvegicus
1.13.11.52 tryptamine
-
 Delftia acidovorans
1.13.11.52 tryptamine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.037
-
 O2 pH 8.0 Rattus norvegicus
1.13.11.52 0.038
-
 O2 pH 7.0 Delftia acidovorans
1.13.11.52 0.25
-
 L-Trp pH 8.0 Rattus norvegicus
1.13.11.52 0.3
-
 L-Trp pH 7.0 Delftia acidovorans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.52 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.52 copper enzyme contains 2 copper moieties Rattus norvegicus
1.13.11.52 copper enzyme contains 2 copper moieties Delftia acidovorans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.52 31000
-
 4 * 31000, SDS-PAGE Delftia acidovorans
1.13.11.52 43000
-
 alpha2beta2, 2 * 43000 + 2 * 43000, SDS-PAGE Rattus norvegicus
1.13.11.52 122000
-
 gel filtration, sucrose density gradient centrifugation, equilibrium sedimentation Delftia acidovorans
1.13.11.52 167000
-
 gel filtration, sucrose density gradient centrifugation, equilibrium sedimentation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-Trp + O2 Rattus norvegicus regulation of enzyme activity L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2 Delftia acidovorans regulation of enzyme activity L-formylkynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Delftia acidovorans
-
-
-
1.13.11.52 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Delftia acidovorans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.52 2.5
-
-
 Rattus norvegicus
1.13.11.52 17
-
-
 Delftia acidovorans

Storage Stability

EC Number Storage Stability Organism
1.13.11.52 pH 7.0, anaerobically stored in 0.1 M potassium phosphate buffer containing L-Trp, quite stable Rattus norvegicus
1.13.11.52 pH 7.0, anaerobically stored in 0.1 M potassium phosphate buffer containing L-Trp, quite stable Delftia acidovorans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 DL-6-fluorotryptophan + O2
-
 Rattus norvegicus ?
-
 ?
1.13.11.52 DL-6-fluorotryptophan + O2
-
 Delftia acidovorans ?
-
 ?
1.13.11.52 DL-6-methyltryptophan
-
 Rattus norvegicus ?
-
 ?
1.13.11.52 L-Trp + O2
-
 Rattus norvegicus L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2
-
 Delftia acidovorans L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2 regulation of enzyme activity Rattus norvegicus L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2 regulation of enzyme activity Delftia acidovorans L-formylkynurenine
-
 ?
1.13.11.52 additional information no activity with D-Trp Rattus norvegicus additional information
-
 ?
1.13.11.52 additional information no activity with D-Trp Delftia acidovorans additional information
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 tetramer 4 * 31000, SDS-PAGE Delftia acidovorans
1.13.11.52 tetramer alpha2beta2, 2 * 43000 + 2 * 43000, SDS-PAGE Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.52 additional information
-
 additional information 2070 per min, formylkynurenine formed Delftia acidovorans
1.13.11.52 additional information
-
 additional information 420 per min, formylkynurenine formed Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme enzyme contains two heme moieties Rattus norvegicus
1.13.11.52 heme enzyme contains two heme moieties Delftia acidovorans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.001
-
 L-5-hydroxytryptophan
-
 Delftia acidovorans
1.13.11.52 0.01
-
 L-5-hydroxytryptophan
-
 Rattus norvegicus
1.13.11.52 0.08
-
 Indolepropionic acid
-
 Delftia acidovorans
1.13.11.52 0.1
-
 tryptamine
-
 Delftia acidovorans
1.13.11.52 0.12
-
 DL-5-fluorotryptophan
-
 Rattus norvegicus
1.13.11.52 0.14
-
 indole
-
 Rattus norvegicus
1.13.11.52 0.19
-
 DL-5-Methyltryptophan
-
 Rattus norvegicus
1.13.11.52 0.21
-
 Indolepropionic acid
-
 Delftia acidovorans
1.13.11.52 0.28
-
 DL-4-methyltryptophan
-
 Rattus norvegicus
1.13.11.52 0.33
-
 DL-4-fluorotryptophan
-
 Rattus norvegicus
1.13.11.52 0.39
-
 DL-5-fluorotryptophan
-
 Delftia acidovorans
1.13.11.52 0.55
-
 DL-5-Methyltryptophan
-
 Delftia acidovorans
1.13.11.52 0.67
-
 DL-4-methyltryptophan
-
 Delftia acidovorans
1.13.11.52 1
-
 DL-4-fluorotryptophan
-
 Delftia acidovorans
1.13.11.52 1.8
-
 tryptamine
-
 Delftia acidovorans
1.13.11.52 2.7
-
 indole
-
 Delftia acidovorans