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Literature summary extracted from

  • Krieg, P.; Kinzig, A.; Ress-Löschke, M.; Vogel, S.; Vanlandingham, B.; Stephan, M.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
    12-Lipoxygenase isoenzymes in mouse skin tumor development (1995), Mol. Carcinog., 14, 118-129.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.31 two cDNA clones encoding the platelet-type and the leukocyte-type isoforms expressed in COS-7 cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.31 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 carcinoma cell most tumors show constitutive overexpression of platelet-type mRNA, leukocyte-type specific transcripts are detectable only in a few tumors Mus musculus
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1.13.11.31 epidermis
-
 Mus musculus
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1.13.11.31 epidermis
-
 Homo sapiens
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1.13.11.31 keratinocyte platelet-type enzyme is the 12-lipoxygenase isoform responsible for the generation of most of the 12-hydroxyeicosateteaenoic acid Mus musculus
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1.13.11.31 leukocyte
-
 Homo sapiens
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1.13.11.31 papilloma cell
-
 Mus musculus
-
1.13.11.31 skin
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Mus musculus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate leukocyte-type enzyme produces 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid, platelet-type enzyme produces only 12-hydroxyeicosatetraenoic acid ?
1.13.11.31 linoleic acid + O2
-
 Mus musculus 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?