Literature summary extracted from

Hamasaki, Y.; Tai, H.H.
Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases (1985), Biochim. Biophys. Acta, 834, 37-41.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.13.11.31	5-Hydroxydopamine	-	Rattus norvegicus
1.13.11.31	6-Hydroxydopamine	-	Rattus norvegicus
1.13.11.31	chlorpromazine	-	Rattus norvegicus
1.13.11.31	eicosatetraynoic acid	-	Rattus norvegicus
1.13.11.31	esculetin	-	Rattus norvegicus
1.13.11.31	fluphenazine	-	Rattus norvegicus
1.13.11.31	gossypol acetic acid	non-competitive with respect to arachidonate	Rattus norvegicus
1.13.11.31	Trifluoperazine	-	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.31	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.31	leukemia cell	basophilic	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.31	arachidonate + O2	i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid	Rattus norvegicus	(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)