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Literature summary extracted from

  • Forbes, B.J.R.; Hamilton, G.A.
    Mechanism and mechanism-based inactivation of 4-hydroxyphenylpyruvate dioxygenase (1994), Bioorg. Chem., 22, 343-361.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 2-thienylpyruvate mechanism-based inhibitor Sus scrofa
1.13.11.27 3-thienylpyruvate mechanism-based inhibitor Sus scrofa
1.13.11.27 4-hydroxytetrafluorophenylpyruvate mechanism-based inhibitor Sus scrofa
1.13.11.27 pentafluorophenylpyruvate competitive Sus scrofa
1.13.11.27 thiophenol oxalate
-
 Sus scrofa
1.13.11.27 thiophenyl oxalate competitive Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 0.041
-
 4-hydroxyphenylpyruvate
-
 Sus scrofa
1.13.11.27 0.05
-
 4-hydroxytetrafluorophenylpyruvate
-
 Sus scrofa
1.13.11.27 0.066
-
 phenylpyruvate
-
 Sus scrofa
1.13.11.27 0.25
-
 3-thienylpyruvate
-
 Sus scrofa
1.13.11.27 0.5
-
 2-thienylpyruvate
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 2-thienylpyruvate + O2
-
 Sus scrofa ? + CO2
-
 ?
1.13.11.27 3-thienylpyruvate + O2
-
 Sus scrofa 3-carboxymethyl-3-thiolene-2-one + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Sus scrofa homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxytetrafluorophenylpyruvate + O2
-
 Sus scrofa ? + CO2
-
 ?
1.13.11.27 phenylpyruvate + O2
-
 Sus scrofa 2-hydroxyphenylacetate + CO2
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 0.014
-
 pentafluorophenylpyruvate
-
 Sus scrofa
1.13.11.27 0.15
-
 thiophenol oxalate
-
 Sus scrofa