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Literature summary extracted from

  • Rundgren, M.
    Multiple forms of human 4-hydroxyphenylpyruvate dioxygenase (II) (1977), J. Biol. Chem., 252, 5085-5093.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 4-hydroxyphenylpyruvate enzyme form 2 and 3, no substrate inhibition is observed for enzyme form 1 Homo sapiens
1.13.11.27 bathophenanthroline
-
 Homo sapiens
1.13.11.27 diethyldithiocarbamate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 0.025
-
 4-hydroxyphenylpyruvate enzyme form 1 Homo sapiens
1.13.11.27 0.027
-
 4-hydroxyphenylpyruvate enzyme form 2 Homo sapiens
1.13.11.27 0.029
-
 4-hydroxyphenylpyruvate enzyme form 3 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.27 63000 67000 enzyme forms 1, 2, and 3, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Homo sapiens
-
 enzyme form 1, 2, and 3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.27 0.51 1.1 enzyme forms 1, 2, and 3 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Homo sapiens homogentisate + CO2
-
 ?
1.13.11.27 phenylpyruvate + O2
-
 Homo sapiens 2-hydroxyphenylacetate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.27 More the multiple enzyme forms are not interconvertible by oxidation, reduction, pyridine inactivation, metal chelator treatment, or treatment with neuraminidase Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.27 4.6
-
 and a second optimum at pH 7.4, enzyme form 3 Homo sapiens
1.13.11.27 5.1
-
 and a second optimum at pH 7.4, enzyme form 1 and 2 Homo sapiens
1.13.11.27 7.4
-
 and a second optimum at pH 5.1 for enzyme form 1 and 2, and at pH 4.6 for enzyme form 3 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 0.4
-
 4-hydroxyphenylpyruvate about, enzyme form 3 Homo sapiens
1.13.11.27 0.7
-
 4-hydroxyphenylpyruvate about, enzyme form 2 Homo sapiens