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Literature summary extracted from

  • Lindstedt, S.; Rundgren, M.
    Inhibition of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P.J. 874 the enol tautomer of the substrate (1982), Biochim. Biophys. Acta, 704, 66-74.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 1,2-dihydroxybenzene-3,5-disulfonic acid inhibition is prevented by ascorbate but not reversed by enol-4-hydroxyphenylpyruvate Pseudomonas sp.
1.13.11.27 4-hydroxyphenylpyruvate interaction of enol-4-hydroxyphenylpyruvate with enzyme-bound Fe3+, formed by autooxidation, causes the substrate inhibition Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 additional information
-
 additional information
-
 Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Pseudomonas sp.
-
-
-
1.13.11.27 Pseudomonas sp. P.J. 874
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Pseudomonas sp. homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Pseudomonas sp. P.J. 874 homogentisate + CO2
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.13.11.27 37
-
 pH 7.5, 0.64 M Tris-HCl, stable for 7.5 min Pseudomonas sp.

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.13.11.27 7.5
-
 37°C, 7.5 min, stable Pseudomonas sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 additional information
-
 additional information
-
 Pseudomonas sp.