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Literature summary extracted from
- 1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity (1995), J. Biol. Chem., 270, 3479-3482.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | cysteine | part of the active site | Homo sapiens |  |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | medicine | target for immunostimulating effect of 1-chloro-2,4-dinitrobenzene as agent in AIDS treatment | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | 1-chloro-2,4-dinitrobenzene | i.e. DNCB; irreversible, with NADPH, alkylation of the active site cysteine disulfide, strong increase in oxidation activity of the enzyme against NADPH | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Homo sapiens | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.8.1.9 | thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | inhibition mechanism | Homo sapiens | |
| 1.8.1.9 | thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | electron transfer in the enzyme complex of apoenzyme, FAD and thioredoxin with NADPH | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin + NADP+ | coupled assay with DTNB | Homo sapiens | thioredoxin disulfide + NADPH | - |
r | |
| 1.8.1.9 | thioredoxin + NADP+ | - |
Homo sapiens | thioredoxin disulfide + NADPH + H+ | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | TR | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.9 | 20 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.9 | 7 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | FAD | - |
Homo sapiens | |
| 1.8.1.9 | NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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