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Literature summary extracted from
- The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (1985), Biochim. Biophys. Acta, 839, 62-70.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | Triton X-100 | - |
Sus scrofa |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | iodoacetate | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.12 | additional information | interfacial character of the enzyme | Sus scrofa | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | Se | Se in selenol form | Sus scrofa | |
| 1.11.1.12 | Se | 1 g-atom Se per mol protein | Sus scrofa | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 20000 | - |
1 * 20000, SDS-PAGE | Sus scrofa |
| 1.11.1.12 | 23000 | - |
gel filtration | Sus scrofa |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.12 | - |
Sus scrofa |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.11.1.12 | 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O | tert-uni ping-pong mechanism | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | heart | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 195.1 | - |
purified enzyme | Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + cardiolipin | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + cumene hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + dilinoleoyl phosphatidylcholine hydroperoxide | and derivatives of dilinoyl phosphatidylcholine hydroperoxide | Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + H2O2 | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + L-alpha-phosphatidylcholine hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + linoleic acid hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | - |
Sus scrofa | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + phosphatidic acid hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + phosphatidylethanolamine hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + phosphatidylserine hydroperoxide | - |
Sus scrofa | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.12 | monomer | 1 * 23000, SDS-PAGE | Sus scrofa |
| 1.11.1.12 | monomer | 1 * 20000, SDS-PAGE | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 7.6 | - |
assay at | Sus scrofa |
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Release 2023.1 (January 2023)
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