Any feedback?
Literature summary extracted from
- Protein disulfide oxidoreductases in bacteria (1994), Trends Biochem. Sci., 19, 169-171.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.2 | periplasm | - |
Escherichia coli | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 21100 | - |
DsbA gene product | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.2 | GSH + protein disulfide | Escherichia coli | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | GSSG + protein-dithiol | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | Escherichia coli | - |
- |
- |
| 1.8.4.2 | Haemophilus influenzae | - |
DsbA homologous | - |
| 1.8.4.2 | Haemophilus influenzae | - |
Por gene | - |
| 1.8.4.2 | Haemophilus influenzae DsbA homologous | - |
DsbA homologous | - |
| 1.8.4.2 | Vibrio cholerae serotype O1 | - |
tcpG gene | - |
| 1.8.4.2 | Vibrio cholerae serotype O1 | - |
DsbA homologous | - |
| 1.8.4.2 | Vibrio cholerae serotype O1 DsbA homologous | - |
DsbA homologous | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.8.4.2 | 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol | C-X-X-C motif in active site for disulfide bonding, either oxidizing, reducing and isomerising activity | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.2 | GSH + protein disulfide | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | Escherichia coli | GSSG + protein-dithiol | - |
r | |
| 1.8.4.2 | additional information | DsbB protein re-oxidizes the reduced DsbA protein | Escherichia coli | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.2 | More | DsbA protein family including periplasmic protein disulfide: thiol oxidoreductases with high homology in amino acid sequences | Escherichia coli |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
