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Literature summary extracted from

  • Chandler, M.L.; Varandani, P.T.
    Kinetic analysis of the mechanism of insulin degradation by glutathione-insulin transhydrogenase (thiol: protein-disulfide oxidoreductase) (1975), Biochemistry, 14, 2107-2115.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.2 GSSG product inhibition Bos taurus
1.8.4.2 additional information overview product inhibition Bos taurus
1.8.4.2 S-Sulfonated A-chain or B-chain of insulin product inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.4.2 additional information
-
 additional information Km values for insulin at various fixed thiol concentrations and for various thiol compounds at fixed insulin concentrations Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.4.2 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol random mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 2,3-dimercaptopropanol + protein disulfide
-
 Bos taurus 2,3-dimercaptopropanol disulfide + protein-dithiol
-
 ?
1.8.4.2 2-mercaptoethanol + protein disulfide
-
 Bos taurus 2-mercaptoethanol disulfide + protein-dithiol
-
 ?
1.8.4.2 dihydrolipoate + protein disulfide
-
 Bos taurus ?
-
 ?
1.8.4.2 dithiothreitol + protein disulfide
-
 Bos taurus ?
-
 ?
1.8.4.2 GSH + insulin
-
 Bos taurus GSSG + reduced insulin chain A and B
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Bos taurus GSSG + protein-dithiol
-
 r
1.8.4.2 GSSG + reduced ribonuclease
-
 Bos taurus GSH + oxidized ribonuclease
-
 ?