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Literature summary extracted from

  • Morris, J.I.; Varandani, P.T.
    Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase) (1988), Biochim. Biophys. Acta, 949, 169-180.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.4.2 phosphatidylethanolamine activates at low concentration Homo sapiens
1.8.4.2 phosphatidylethanolamine activates at low concentration Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.2 characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence Homo sapiens
1.8.4.2 characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.2 GSH + protein disulfide Homo sapiens feedback control via insulin in the liver GSSG + protein-dithiol
-
 ?
1.8.4.2 GSH + protein disulfide Rattus norvegicus feedback control via insulin in the liver GSSG + protein-dithiol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.2 Homo sapiens
-
-
-
1.8.4.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.2 adipose tissue
-
 Rattus norvegicus
-
1.8.4.2 brain
-
 Rattus norvegicus
-
1.8.4.2 kidney
-
 Homo sapiens
-
1.8.4.2 kidney
-
 Rattus norvegicus
-
1.8.4.2 liver
-
 Homo sapiens
-
1.8.4.2 liver
-
 Rattus norvegicus
-
1.8.4.2 lung
-
 Homo sapiens
-
1.8.4.2 lung
-
 Rattus norvegicus
-
1.8.4.2 skeletal muscle
-
 Rattus norvegicus
-
1.8.4.2 spleen
-
 Rattus norvegicus
-
1.8.4.2 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.2 GSH + insulin
-
 Homo sapiens GSSG + reduced insulin chain A and B
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Homo sapiens GSSG + protein-dithiol
-
 ?
1.8.4.2 GSH + protein disulfide
-
 Rattus norvegicus GSSG + protein-dithiol
-
 ?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Homo sapiens GSSG + protein-dithiol
-
 ?
1.8.4.2 GSH + protein disulfide feedback control via insulin in the liver Rattus norvegicus GSSG + protein-dithiol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.2 GIT
-
 Homo sapiens
1.8.4.2 GIT
-
 Rattus norvegicus
1.8.4.2 More
-
 Rattus norvegicus
1.8.4.2 More protein-disulfide isomerase EC 5.3.4.1 and protein-disulfide oxidoreductase EC 1.8.4.2 are identical and form the glutathione-insulin transhydrogenase Homo sapiens